Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2022-11, Vol.263, p.119639-119639, Article 119639
• Main Authors: Togo, Masaya, Matsumoto, Riki, Usami, Kiyohide, Kobayashi, Katsuya, Takeyama, Hirofumi, Nakae, Takuro, Shimotake, Akihiro, Kikuchi, Takayuki, Yoshida, Kazumichi, Matsuhashi, Masao, Kunieda, Takeharu, Miyamoto, Susumu, Takahashi, Ryosuke, Ikeda, Akio
• Format: Article
• Language: English
• Subjects: Brain Mapping; Brain tumors; Cognitive ability; Cortex (cingulate); Cortex (parietal); Cortico-cortical evoked potential (CCEP); Default mode network; Electrical stimuli; Electrodes; Electroencephalography; Epilepsies, Partial; Epilepsy; Evoked Potentials - physiology; Gyrus Cinguli; Humans; Limbic System; Magnetic Resonance Imaging; Medial parietal cortices; Neural networks; Neural Pathways - physiology; Occipital lobe; Parietal Lobe - physiology; Patients; Posterior cingulate cortex; Precuneus; Superior parietal lobule
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2022.119639

The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation (p