Significant increase of serum extracellular vesicle-packaged growth differentiation factor 15 in type 2 diabetes mellitus: a cross-sectional study

Growth differentiation factor 15 (GDF15) is a stress-inducible factor involved in the inflammatory progression of many complications, including type 2 diabetes mellitus (T2DM). Growing evidence suggests that molecules in extracellular vesicles (EVs) are associated with diabetes or diabetes-related c...

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Published in:European journal of medical research 2023-01, Vol.28 (1), p.37-37, Article 37
Main Authors: Zhao, Wen, Li, Xinwei, Li, Xinxin, Peng, Lu, Li, Yu, Du, Yunhui, He, Jianxun, Qin, Yanwen, Zhang, Huina
Format: Article
Language:English
Subjects:
Alcohol
Analysis
Biomarker
Biomarkers
Blood diseases
Blood Glucose
Cholesterol
Cross-Sectional Studies
Dextrose
Diabetes
Diabetes Mellitus, Type 2
Extracellular Vesicles
Glucose
Glycated Hemoglobin
Glycosylated hemoglobin
Growth
Growth Differentiation Factor 15
Hemoglobin
High density lipoprotein
Hormone replacement therapy
Hospitals
Humans
Medical research
Plasma
Proteins
Sample size
Serum
Statistical analysis
Type 2 diabetes
Type 2 diabetes mellitus
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Summary:Growth differentiation factor 15 (GDF15) is a stress-inducible factor involved in the inflammatory progression of many complications, including type 2 diabetes mellitus (T2DM). Growing evidence suggests that molecules in extracellular vesicles (EVs) are associated with diabetes or diabetes-related complications. However, the correlation between serum extracellular vesicle-derived growth differentiation factor15 (EV-GDF15) and T2DM is unknown. The aim of this cross-sectional study is to investigate whether serum EV-GDF15 is associated with T2DM incidence. 116 individuals, including 78 T2DM and 38 non-T2DM, were recruited as participants. The concentrations of serum EV-GDF15 and serum GDF15 were determined by Luminex assay. Serum EVs were obtained by ultracentrifugation. Multivariate stepwise regression analysis was used to determine the association between serum GDF15 levels and fasting plasma glucose (FPG) as well as glycated hemoglobin (HbA1c). The association of serum EV-GDF15 levels with T2DM was determined by multivariate logistic regression analysis. Our data showed that the levels of serum EV-GDF15 and serum GDF15 were significantly increased in T2DM patients compared with non-T2DM subjects (EV-GDF15 levels, 13.68 (6.61-23.44) pg/mL vs. 5.56 (3.44-12.09) pg/mL, P 
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-023-01009-6