Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value

Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous ph...

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Bibliographic Details
Published in:Mediators of inflammation 2021, Vol.2021, p.8481013-7
Main Authors: Shao, Yuanyuan, Pan, Xiaofeng, Fu, Rong
Format: Article
Language:English
Subjects:
Adaptive immunity
Antigens
Apoptosis
Autoimmune diseases
Autoimmunity
B cells
Cardiovascular disease
CD4-Positive T-Lymphocytes - ultrastructure
CD8-Positive T-Lymphocytes - ultrastructure
Cell interactions
Cell signaling
Chemokines
Cytokines
Esophagus
Exosomes
Exosomes - physiology
Extracellular vesicles
Health aspects
Humans
Immunology
Infectious diseases
Inflammation
Ligands
Lymphocytes
Lymphocytes T
Membrane vesicles
Mitochondrial DNA
Pathogenesis
Pathogens
Physiological aspects
Physiology
Proteins
Review
RNA
T cell receptors
T cells
T-Lymphocytes - ultrastructure
T-Lymphocytes, Regulatory - ultrastructure
Tumor necrosis factor-TNF
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Summary:Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous physiological and pathological processes. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in inflammatory responses, autoimmunity, and infectious diseases. In this review, we will summarize the function of T cell-derived exosomes and their therapeutic potential.
ISSN:0962-9351
1466-1861
DOI:10.1155/2021/8481013