Delayed Leukoencephalopathy: Three Case Reports and a Literature Review

Delayed leukoencephalopathy (DL) is a rare entity associated with cerebral hypoxia and heroin consumption. We describe the clinical course of three cases of DL due to non-heroin drug use. We describe the cases of three DL patients admitted to our hospital in 2012. These cases contribute to the aetio...

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Bibliographic Details
Published in:European journal of case reports in internal medicine 2017-03, Vol.4 (2), p.000511
Main Authors: Torralba-Morón, Ángel, Ortiz-Imedio, Juan, Morales-Conejo, Montserrat, Ruiz-Morales, Juan, Guerra-Vales, Juan-Manuel
Format: Article
Language:English
Subjects:
Delayed Leukoencephalopathy
Methadone
Pale Globes
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Summary:Delayed leukoencephalopathy (DL) is a rare entity associated with cerebral hypoxia and heroin consumption. We describe the clinical course of three cases of DL due to non-heroin drug use. We describe the cases of three DL patients admitted to our hospital in 2012. These cases contribute to the aetiological spectrum of DL since multifactorial causes could account for the clinical symptoms. Substances toxic to the CNS can damage the CNS directly (direct toxicity) or by depressing the respiratory centre (cerebral hypoxia).As clinical manifestations can appear after a time lag, we recommend a period of initial monitoring.Histological and radiological findings can contribute to better understanding of the pathophysiological mechanisms and causes involved.
ISSN:2284-2594
2284-2594
DOI:10.12890/2016_000511