The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases

The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-01, Vol.22 (2), p.721
Main Authors: Eshac, Youssof, Redfern, Rachel L, Aakalu, Vinay Kumar
Format: Article
Language:English
Subjects:
Amino acids
Animals
Antiinfectives and antibacterials
Antimicrobial agents
antimicrobial peptide
Antimicrobial peptides
Biomarkers
Biosynthetic Pathways
Cell adhesion & migration
Committees
Cornea
Cornea - immunology
Cornea - metabolism
Cytokines
Defensins - genetics
Defensins - metabolism
Disease
Disease Management
Disease Susceptibility
dry eye disease
Dry Eye Syndromes - etiology
Dry Eye Syndromes - metabolism
Dry Eye Syndromes - pathology
Dry Eye Syndromes - therapy
Eye diseases
Gene Expression
Homeostasis
Humans
Immune response
Immune system
Immunity, Innate
Immunomodulation
Inflammation
innate immune system
Innate immunity
Literature reviews
Microorganisms
Neutrophils
ocular surface disease
Pathogenesis
Pathogens
Peptides
Pore Forming Cytotoxic Proteins - genetics
Pore Forming Cytotoxic Proteins - metabolism
Protein Transport
Review
Roles
Toll-Like Receptors - genetics
Toll-Like Receptors - metabolism
Wound healing
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Summary:The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22020721