Modular DNA strand-displacement controllers for directing material expansion

Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and nec...

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Bibliographic Details
Published in:Nature communications 2018-09, Vol.9 (1), p.3766-8, Article 3766
Main Authors: Fern, Joshua, Schulman, Rebecca
Format: Article
Language:English
Subjects:
639/301/54/992
639/301/923/1027
639/925/926
Actuation
BASIC BIOLOGICAL SCIENCES
Controllers
Crosslinking
Deoxyribonucleic acid
DNA
External stimuli
Humanities and Social Sciences
Hydrogels
multidisciplinary
Polymers
Regenerative Medicine
Robotics
Science
Science & Technology - Other Topics
Science (multidisciplinary)
Stimuli
Swelling
Tissue Engineering - methods
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Description
Summary:Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-06218-w