Prevalence, clinical features, and survival outcome trends of 627 patients with primary cutaneous lymphoma over 29 years: a retrospective review from single tertiary center in Korea

• Published in: Scientific reports 2024-08, Vol.14 (1), p.20118-9, Article 20118
• Main Authors: Moon, Ik Jun, Won, Chong Hyun, Chang, Sung Eun, Park, Chan-Sik, Yoon, Dok-Hyun, Song, Si Yeol, Lee, Mi Woo, Lee, Woo Jin
• Format: Article
• Language: English
• Subjects: 692/4028/67/1813; 692/699/1541/1990/291; Adolescent; Adult; Aged; Aged, 80 and over; B-cell lineage lymphomas; CD4 antigen; Cell lineage; Child; Female; Humanities and Social Sciences; Humans; Incidence; Lymphocytes; Lymphocytes B; Lymphocytes T; Lymphoma; Lymphoma, B-Cell - epidemiology; Lymphoma, B-Cell - mortality; Lymphoma, B-Cell - pathology; Lymphoma, T-Cell, Cutaneous - epidemiology; Lymphoma, T-Cell, Cutaneous - mortality; Lymphoma, T-Cell, Cutaneous - pathology; Male; Middle Aged; multidisciplinary; Mycosis; Mycosis fungoides; Prevalence; Primary cutaneous lymphoma; Republic of Korea - epidemiology; Retrospective Studies; Science; Science (multidisciplinary); Skin Neoplasms - epidemiology; Skin Neoplasms - mortality; Skin Neoplasms - pathology; Survival; Survival Analysis; T-/NK-cell lineage; T-cell lymphoma; Tertiary Care Centers; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-71210-y

The relative frequency of primary cutaneous lymphoma (PCL) subtypes shows wide variation across different geographical regions. This retrospective study was conducted in a tertiary referral center located in Korea to describe the relative frequency, demographics, survival outcomes, and temporal trend in PCL. A total of 627 PCL cases diagnosed between January 1994 and December 2022 were included. The majority of PCL cases (87.2%) were of T-/NK-cell lineage (CTCL), while the remaining cases (12.8%) were B-cell lineage lymphomas (CBCL). The prevalence of mycosis fungoides (MF) in CTCL increased significantly over time, while other CTCL subtypes, including primary cutaneous extranodal NK/T-cell lymphoma and subcutaneous panniculitis-like T-cell lymphoma (SPTCL), decreased in frequency. Notably, the prevalence of CD4-positive small/medium T-cell lymphoproliferative disorder showed a substantial increase over time. Primary cutaneous marginal zone lymphoma was consistently the commonest CBCL subtype. Survival analysis demonstrated that CTCL had a more favorable 5-year overall survival (OS) than CBCL. OS rate of MF, SPTCL, and primary cutaneous peripheral T-cell lymphoma, NOS improved significantly over time. This study provides comprehensive insights into the dynamic change in the relative frequency and overall survival of PCL subtypes over time.