Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug

Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules w...

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Bibliographic Details
Published in:Marine drugs 2016-01, Vol.14 (1), p.1-1
Main Authors: García-Vilas, Javier A, Martínez-Poveda, Beatriz, Quesada, Ana R, Medina, Miguel Ángel
Format: Article
Language:English
Subjects:
(+)-aeroplysinin-1
Acetonitriles - chemistry
Acetonitriles - pharmacology
angiogenesis
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
cancer
Cyclohexenes - chemistry
Cyclohexenes - pharmacology
Gram-Positive Bacteria - drug effects
Humans
inflammation
marine drugs
Porifera
Review
Seawater
sponges
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Summary:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.
ISSN:1660-3397
1660-3397
DOI:10.3390/md14010001