Antiviral activity of Taurisolo® during bovine alphaherpesvirus 1 infection

•The grape pomace extract Taurisolo® possesses antiviral activity against BoAHV-1.•Taurisolo® increases cell viability and reduces virus yield following infection.•Taurisolo® induces a modulation of AhR during BoAHV-1 infection. Bovine alphaherpesvirus 1 (BoAHV-1), the pathogen causing Infectious Bo...

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Bibliographic Details
Published in:Virus research 2023-10, Vol.336, p.199217-199217, Article 199217
Main Authors: Cerracchio, Claudia, Amoroso, Maria Grazia, Piccolo, Marialuisa, Ferraro, Maria Grazia, Nocera, Francesca Paola, De Martino, Luisa, Serra, Francesco, Irace, Carlo, Tenore, Gian Carlo, Novellino, Ettore, Santamaria, Rita, Fiorito, Filomena
Format: Article
Language:English
Subjects:
AhR
bICP0
BoAHV-1
MDBK
Taurisolo
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Summary:•The grape pomace extract Taurisolo® possesses antiviral activity against BoAHV-1.•Taurisolo® increases cell viability and reduces virus yield following infection.•Taurisolo® induces a modulation of AhR during BoAHV-1 infection. Bovine alphaherpesvirus 1 (BoAHV-1), the pathogen causing Infectious Bovine Rhinotracheitis (IBR) and predisposing to polymicrobial infections in cattle, provokes farm economic losses and trading restrictions in the world. However, nontoxic antiviral agents for BoAHV-1 infection are still unavailable, but plant extracts, such as flavonoid derivatives possess activity against BoAHV-1. Taurisolo®, a nutraceutical produced by Aglianico grape pomace, has recently shown promising antiviral activity. Herein, the potential activity of Taurisolo® during BoAHV-1 infection in Madin Darby bovine kidney (MDBK) cells was tested. Taurisolo® enhanced cell viability and reduced morphological death signs in BoAHV-1-infected cells. Moreover, Taurisolo® influenced the expression of bICP0, the key regulatory protein of BoAHV-1, and it strongly diminished virus yield. These effects were associated with an up-regulation of aryl hydrocarbon receptor (AhR), a transcription factor involved in microbial metabolism and immune response. In conclusion, our findings indicate that Taurisolo® may represent a potential antiviral agent against BoAHV-1 infection. Noteworthy, AhR could be involved in the observed effects and become a new target in antiviral therapy. [Display omitted]
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2023.199217