Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Level is Related to Clinical Prognosis In Patients with Acute Atherosclerosis-related Ischemic Stroke

• Published in: Clinical and applied thrombosis/hemostasis 2021, Vol.27, p.10760296211059500-10760296211059500
• Main Authors: Yang, Xiaoli, Hou, Duanlu, Liu, Jianjun, Wang, Tianyao, Luo, Yufan, Sun, Wenbo, Li, Chen, Shen, Liwei, Liu, Wenpeng, Wu, Danhong
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Atherosclerosis; Female; Humans; Ischemic Stroke - blood; Ischemic Stroke - diagnosis; Low density lipoprotein receptors; Male; Middle Aged; Original Manuscript; Prognosis; Risk Factors; Scavenger Receptors, Class E - metabolism; Stroke
• ISSN: 1076-0296; 1938-2723
• DOI: 10.1177/10760296211059500

To investigate the associations between soluble Lectin-like Oxidized Low-density lipoprotein receptor-1 (sLOX-1) and clinical prognosis, especially infarct volume in patients with acute atherosclerosis-related ischemic stroke. We recruited acute ischemic stroke patients within 3 days after onset. Patients were stratified into 3 groups by sLOX-1 level. Initial stroke severity was assessed using the National Institutes of Health Stroke Scale scores, and infarct volume was measured using DWI by ITK-SNAP software. The clinical prognosis was evaluated by DWI volume, clinical response at discharge, and functional outcome at 90 days. Spearman rank correlation analysis was used to examine associations between circulating sLOX-1 levels and infarct volumes. Logistic regression was used to explore the relationship between sLOX-1 levels and clinical prognosis. A total of 207 patients were included in our study. The median DWI volume in the lowest sLOX-1 tertile was 1.98 cm3, smaller than 4.26 cm3 in the highest sLOX-1 group. The Spearman rank correlation coefficient between sLOX-1 levels and DWI volume was 0.47 (P