Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections

An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Addition...

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Bibliographic Details
Published in:Pathogens (Basel) 2023-08, Vol.12 (8), p.1033
Main Authors: Hetta, Helal F., Ramadan, Yasmin N., Al-Kadmy, Israa M. S., Ellah, Noura H. Abd, Shbibe, Lama, Battah, Basem
Format: Article
Language:English
Subjects:
Abscesses
Antifungal agents
antifungal resistance
Biofilms
Candida auris
Chronic obstructive pulmonary disease
Clinical trials
Decontamination
Drugs
Epidemics
Epidemiology
Fatalities
Fungal infections
Fungi
Illnesses
Immune system
Immunocompetence
Immunodeficiency
MDR
Meningitis
Mortality
Multidrug resistance
Nanoparticles
Nanotechnology
Nosocomial infection
Nosocomial infections
Outbreaks
Pandemics
Patients
Review
Skin
Staphylococcus infections
Yeasts
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Summary:An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens12081033