HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research

The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an approp...

Full description

Saved in:
Bibliographic Details
Published in:NPJ systems biology and applications 2017-01, Vol.3 (1), p.1-7, Article 1
Main Authors: Furutani, Kazuharu, Tsumoto, Kunichika, Kurachi, Yoshihisa
Format: Article
Language:English
Subjects:
631/114/794
631/443
631/553/2694
631/57
Bioinformatics
Biomedical and Life Sciences
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Computer applications
Life Sciences
Pharmacokinetics
Physiology
Review
Review Article
Systems Biology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research.
ISSN:2056-7189
2056-7189
DOI:10.1038/s41540-016-0001-0