Autologous platelet rich plasma injection can be effective in the management of osteoarthritis of the knee: impact on IL-1 β, TNF-α, hs-CRP

To analyze the clinical efficacy of autologous platelet rich plasma (PRP) injection in the treatment of knee osteoarthritis (KOA) and its influence on related biomarkers such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). 150 stu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic surgery and research 2024-10, Vol.19 (1), p.703-8, Article 703
Main Authors: Qiao, Jiajia, Guo, Xiaojun, Zhang, Ling, Zhao, Hongbin, He, Xuehua
Format: Article
Language:English
Subjects:
Aged
Autologous PRP injection
Biomarkers
Biomarkers - blood
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Female
Humans
Injections, Intra-Articular
Interleukin-1beta - blood
Knee joint function
Knee osteoarthritis
Male
Middle Aged
Motor function
Osteoarthritis, Knee - blood
Osteoarthritis, Knee - therapy
Platelet-Rich Plasma
Treatment Outcome
Tumor Necrosis Factor-alpha - blood
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To analyze the clinical efficacy of autologous platelet rich plasma (PRP) injection in the treatment of knee osteoarthritis (KOA) and its influence on related biomarkers such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). 150 study subjects are randomly selected from KOA patients received treatment in the Third Hospital of Bethune Hospital from January 2022 to January 2023. After enrollment, patients are randomly numbered 1-100. 75 patients with odd and even numbers are included in the control group and the observation group, respectively. The former is cured with etocoxib, while the latter is treated with autologous PRP injection based on this. The clinical efficacy, relevant biomarkers (IL-1β, TNF-α, hs-CRP), and Lysholm knee score scale and Fugl Meyer assessment (FMA) scores are compared and analyzed. The total effective rate of 94.67% (71/75) in the observation group was higher than 84.00% (63/75) in the other one group (P  0.05. When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels within the group were lower than before treatment, while the Lysholm knee joint score and FMA scale score were higher than before treatment (P 
ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-024-05060-9