Autologous platelet rich plasma injection can be effective in the management of osteoarthritis of the knee: impact on IL-1 β, TNF-α, hs-CRP

To analyze the clinical efficacy of autologous platelet rich plasma (PRP) injection in the treatment of knee osteoarthritis (KOA) and its influence on related biomarkers such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). 150 stu...

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Published in:Journal of orthopaedic surgery and research 2024-10, Vol.19 (1), p.703-8, Article 703
Main Authors: Qiao, Jiajia, Guo, Xiaojun, Zhang, Ling, Zhao, Hongbin, He, Xuehua
Format: Article
Language:English
Subjects:
Aged
Autologous PRP injection
Biomarkers
Biomarkers - blood
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Female
Humans
Injections, Intra-Articular
Interleukin-1beta - blood
Knee joint function
Knee osteoarthritis
Male
Middle Aged
Motor function
Osteoarthritis, Knee - blood
Osteoarthritis, Knee - therapy
Platelet-Rich Plasma
Treatment Outcome
Tumor Necrosis Factor-alpha - blood
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Guo, Xiaojun
Zhang, Ling
Zhao, Hongbin
He, Xuehua
description To analyze the clinical efficacy of autologous platelet rich plasma (PRP) injection in the treatment of knee osteoarthritis (KOA) and its influence on related biomarkers such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). 150 study subjects are randomly selected from KOA patients received treatment in the Third Hospital of Bethune Hospital from January 2022 to January 2023. After enrollment, patients are randomly numbered 1-100. 75 patients with odd and even numbers are included in the control group and the observation group, respectively. The former is cured with etocoxib, while the latter is treated with autologous PRP injection based on this. The clinical efficacy, relevant biomarkers (IL-1β, TNF-α, hs-CRP), and Lysholm knee score scale and Fugl Meyer assessment (FMA) scores are compared and analyzed. The total effective rate of 94.67% (71/75) in the observation group was higher than 84.00% (63/75) in the other one group (P  0.05. When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels within the group were lower than before treatment, while the Lysholm knee joint score and FMA scale score were higher than before treatment (P 
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After enrollment, patients are randomly numbered 1-100. 75 patients with odd and even numbers are included in the control group and the observation group, respectively. The former is cured with etocoxib, while the latter is treated with autologous PRP injection based on this. The clinical efficacy, relevant biomarkers (IL-1β, TNF-α, hs-CRP), and Lysholm knee score scale and Fugl Meyer assessment (FMA) scores are compared and analyzed. The total effective rate of 94.67% (71/75) in the observation group was higher than 84.00% (63/75) in the other one group (P &lt; 0.05). Before treatment, the comparison in IL-1β, TNF-α, hs-CRP, Lysholm knee joint score, and FMA scale score are with P &gt; 0.05. When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels within the group were lower than before treatment, while the Lysholm knee joint score and FMA scale score were higher than before treatment (P &lt; 0.05). When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels and the Lysholm knee joint and FMA scale scores in the observation group were lower and higher than those in the other one group, respectively (P &lt; 0.05). 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After enrollment, patients are randomly numbered 1-100. 75 patients with odd and even numbers are included in the control group and the observation group, respectively. The former is cured with etocoxib, while the latter is treated with autologous PRP injection based on this. The clinical efficacy, relevant biomarkers (IL-1β, TNF-α, hs-CRP), and Lysholm knee score scale and Fugl Meyer assessment (FMA) scores are compared and analyzed. The total effective rate of 94.67% (71/75) in the observation group was higher than 84.00% (63/75) in the other one group (P &lt; 0.05). Before treatment, the comparison in IL-1β, TNF-α, hs-CRP, Lysholm knee joint score, and FMA scale score are with P &gt; 0.05. When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels within the group were lower than before treatment, while the Lysholm knee joint score and FMA scale score were higher than before treatment (P &lt; 0.05). When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels and the Lysholm knee joint and FMA scale scores in the observation group were lower and higher than those in the other one group, respectively (P &lt; 0.05). The application of autologous PRP injection therapy in KOA patients can significantly improve their levels of related biomarkers, effectively improve knee joint function and motor function, and have good clinical efficacy.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>39478604</pmid><doi>10.1186/s13018-024-05060-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Autologous PRP injection
Biomarkers
Biomarkers - blood
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Female
Humans
Injections, Intra-Articular
Interleukin-1beta - blood
Knee joint function
Knee osteoarthritis
Male
Middle Aged
Motor function
Osteoarthritis, Knee - blood
Osteoarthritis, Knee - therapy
Platelet-Rich Plasma
Treatment Outcome
Tumor Necrosis Factor-alpha - blood
title Autologous platelet rich plasma injection can be effective in the management of osteoarthritis of the knee: impact on IL-1 β, TNF-α, hs-CRP
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