Multi-Targeted Therapies in Non-Small Cell Lung Cancer

Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signaling process leading to cancer cell proliferation and to the neoplastic phenotype supp...

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Bibliographic Details
Published in:Cancer biology & medicine 2011-12, Vol.8 (4), p.220-223
Main Authors: Wang, Kai, Wei, Jin
Format: Article
Language:English
Subjects:
Cell proliferation
Lung cancer
Malignancy
Medicine
Medicine & Public Health
multi-targeted therapies
non-small cell lung cancer
Non-small cell lung carcinoma
Oncology
Phenotypes
信令过程
复杂性
异质性
治疗方式
细胞增殖
肿瘤细胞
非小细胞肺癌
靶向治疗
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Description
Summary:Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signaling process leading to cancer cell proliferation and to the neoplastic phenotype supports the necessity of interfering at different stages to avoid cancer cell resistance to therapy. For this reason, new strategies for the simultaneous inhibition of multiple molecular targets are being pursued.
ISSN:1674-5361
2095-3941
1868-324X
DOI:10.1007/s11805-011-0584-6