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Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan
Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which co...
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| Published in: | BMC endocrine disorders 2019-10, Vol.19 (1), p.107-107, Article 107 |
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| container_end_page | 107 |
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| container_title | BMC endocrine disorders |
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| creator | Alkhatatbeh, Mohammad J Abdalqader, Nedaa A Alqudah, Mohammad A Y |
| description | Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which could be associated with seizures and unconsciousness. This study aimed to assess IAH, frequency of hypoglycemia, severe hypoglycemia and intensity of hypoglycemic symptoms among children and adolescents with Type 1 DM in North of Jordan.
Data were collected from 94 children and adolescents with Type 1 DM. Clarke's and Edinburgh surveys were used to assess IAH and individual symptoms of hypoglycemia, respectively. Frequency of hypoglycemia and other related information were obtained by self-reporting or from medical records.
16.0% of participants were having IAH, 66.0% of participants reported recurrent hypoglycemia (>once/month) and 18.0% of participants developed ≥1 severe hypoglycemia during the previous year. IAH was not associated with age, gender, duration of DM, HbA1c, insulin regimen, adherence to insulin or development of severe hypoglycemia (p-values> 0.05). Instead, IAH was associated with frequency of hypoglycemia during the previous 6 months (p-value |
| doi_str_mv | 10.1186/s12902-019-0441-9 |
| format | article |
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Data were collected from 94 children and adolescents with Type 1 DM. Clarke's and Edinburgh surveys were used to assess IAH and individual symptoms of hypoglycemia, respectively. Frequency of hypoglycemia and other related information were obtained by self-reporting or from medical records.
16.0% of participants were having IAH, 66.0% of participants reported recurrent hypoglycemia (>once/month) and 18.0% of participants developed ≥1 severe hypoglycemia during the previous year. IAH was not associated with age, gender, duration of DM, HbA1c, insulin regimen, adherence to insulin or development of severe hypoglycemia (p-values> 0.05). Instead, IAH was associated with frequency of hypoglycemia during the previous 6 months (p-value< 0.01). Hunger, tiredness, dizziness, drowsiness, inability to concentrate, trembling and weakness were the most common symptoms felt by participants when they develop hypoglycemia. Hunger was the only common symptom that was significantly higher in children compared to adolescent (p-value < 0.01).
This study has reported low prevalence of IAH in children and adolescents with Type 1 DM in North of Jordan. IAH was more common in subjects with more frequent hypoglycemia.</description><identifier>ISSN: 1472-6823</identifier><identifier>EISSN: 1472-6823</identifier><identifier>DOI: 10.1186/s12902-019-0441-9</identifier><identifier>PMID: 31651281</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Awareness ; Biomarkers - analysis ; Blood Glucose - analysis ; Blood Glucose Self-Monitoring ; Care and treatment ; Child ; Child, Preschool ; Children ; Complications and side effects ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes research ; Diabetes therapy ; Diagnosis ; Female ; Follow-Up Studies ; Glycosylated hemoglobin ; Health Knowledge, Attitudes, Practice ; Humans ; Hypoglycemia ; Hypoglycemia - chemically induced ; Hypoglycemia - epidemiology ; Hypoglycemia - psychology ; Hypoglycemic Agents - adverse effects ; Insulin ; Jordan - epidemiology ; Juvenile diabetes ; Male ; Medical records ; Prevalence ; Prognosis ; Seizures (Medicine) ; Self care (Health) ; Type 1 diabetes</subject><ispartof>BMC endocrine disorders, 2019-10, Vol.19 (1), p.107-107, Article 107</ispartof><rights>COPYRIGHT 2019 BioMed Central Ltd.</rights><rights>The Author(s). 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-f377cc39dc48f53495812128aee0489ed8cc6379022756dff81e62c58273c1883</citedby><cites>FETCH-LOGICAL-c532t-f377cc39dc48f53495812128aee0489ed8cc6379022756dff81e62c58273c1883</cites><orcidid>0000-0002-9490-0979</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814051/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814051/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27906,27907,36995,53773,53775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31651281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alkhatatbeh, Mohammad J</creatorcontrib><creatorcontrib>Abdalqader, Nedaa A</creatorcontrib><creatorcontrib>Alqudah, Mohammad A Y</creatorcontrib><title>Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan</title><title>BMC endocrine disorders</title><addtitle>BMC Endocr Disord</addtitle><description>Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which could be associated with seizures and unconsciousness. This study aimed to assess IAH, frequency of hypoglycemia, severe hypoglycemia and intensity of hypoglycemic symptoms among children and adolescents with Type 1 DM in North of Jordan.
Data were collected from 94 children and adolescents with Type 1 DM. Clarke's and Edinburgh surveys were used to assess IAH and individual symptoms of hypoglycemia, respectively. Frequency of hypoglycemia and other related information were obtained by self-reporting or from medical records.
16.0% of participants were having IAH, 66.0% of participants reported recurrent hypoglycemia (>once/month) and 18.0% of participants developed ≥1 severe hypoglycemia during the previous year. IAH was not associated with age, gender, duration of DM, HbA1c, insulin regimen, adherence to insulin or development of severe hypoglycemia (p-values> 0.05). Instead, IAH was associated with frequency of hypoglycemia during the previous 6 months (p-value< 0.01). Hunger, tiredness, dizziness, drowsiness, inability to concentrate, trembling and weakness were the most common symptoms felt by participants when they develop hypoglycemia. Hunger was the only common symptom that was significantly higher in children compared to adolescent (p-value < 0.01).
This study has reported low prevalence of IAH in children and adolescents with Type 1 DM in North of Jordan. IAH was more common in subjects with more frequent hypoglycemia.</description><subject>Adolescent</subject><subject>Awareness</subject><subject>Biomarkers - analysis</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose Self-Monitoring</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes research</subject><subject>Diabetes therapy</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycosylated hemoglobin</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - chemically induced</subject><subject>Hypoglycemia - epidemiology</subject><subject>Hypoglycemia - psychology</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Insulin</subject><subject>Jordan - epidemiology</subject><subject>Juvenile diabetes</subject><subject>Male</subject><subject>Medical records</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Seizures (Medicine)</subject><subject>Self care (Health)</subject><subject>Type 1 diabetes</subject><issn>1472-6823</issn><issn>1472-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkl1rFDEUhgdRbK3-AG8k4I03U_M5k9wIpfixUvBGr0M2OdlNmZmsyWzL_nvPuLV0QXKRcPK-D-ckb9O8ZfSSMd19rIwbylvKTEulZK151pwz2fO201w8f3I-a17Veksp6zWnL5szwTrFuGbnTV6NO5cKBOLuXYEJaiU5ku1hlzfDwcOYHEkT8ds0BLwmbkJlyANUD9NcyX2at2Q-7IAwEpJbwwyVjDAMad7XxTnlggpEfs8luOl18yK6ocKbh_2i-fXl88_rb-3Nj6-r66ub1ivB5zaKvvdemOCljkpIozTj2LEDoFIbCNr7TvQ4Pe9VF2LUDDrulea98ExrcdGsjtyQ3a3dlTS6crDZJfu3kMvGujInP4AV3EgXOxXXQcgejMOHkZwyxnsIgStkfTqydvv1CGEZvLjhBHp6M6Wt3eQ72yGIKoaADw-Akn_voc52TPh-w-AmyPtquaBGUYWTo_T9Ubpx2FqaYkaiX-T2qqNSSdkbiarL_6hwBfwwnyeICesnBnY0-JJrLRAfu2fULlmyxyxZzJJdsmQNet49HfvR8S884g-wlMO8</recordid><startdate>20191024</startdate><enddate>20191024</enddate><creator>Alkhatatbeh, Mohammad J</creator><creator>Abdalqader, Nedaa A</creator><creator>Alqudah, Mohammad A Y</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9490-0979</orcidid></search><sort><creationdate>20191024</creationdate><title>Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan</title><author>Alkhatatbeh, Mohammad J ; Abdalqader, Nedaa A ; Alqudah, Mohammad A Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-f377cc39dc48f53495812128aee0489ed8cc6379022756dff81e62c58273c1883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Awareness</topic><topic>Biomarkers - analysis</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose Self-Monitoring</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complications and side effects</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes research</topic><topic>Diabetes therapy</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycosylated hemoglobin</topic><topic>Health Knowledge, Attitudes, Practice</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - chemically induced</topic><topic>Hypoglycemia - epidemiology</topic><topic>Hypoglycemia - psychology</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Insulin</topic><topic>Jordan - epidemiology</topic><topic>Juvenile diabetes</topic><topic>Male</topic><topic>Medical records</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Seizures (Medicine)</topic><topic>Self care (Health)</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alkhatatbeh, Mohammad J</creatorcontrib><creatorcontrib>Abdalqader, Nedaa A</creatorcontrib><creatorcontrib>Alqudah, Mohammad A Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC endocrine disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alkhatatbeh, Mohammad J</au><au>Abdalqader, Nedaa A</au><au>Alqudah, Mohammad A Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan</atitle><jtitle>BMC endocrine disorders</jtitle><addtitle>BMC Endocr Disord</addtitle><date>2019-10-24</date><risdate>2019</risdate><volume>19</volume><issue>1</issue><spage>107</spage><epage>107</epage><pages>107-107</pages><artnum>107</artnum><issn>1472-6823</issn><eissn>1472-6823</eissn><abstract>Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which could be associated with seizures and unconsciousness. This study aimed to assess IAH, frequency of hypoglycemia, severe hypoglycemia and intensity of hypoglycemic symptoms among children and adolescents with Type 1 DM in North of Jordan.
Data were collected from 94 children and adolescents with Type 1 DM. Clarke's and Edinburgh surveys were used to assess IAH and individual symptoms of hypoglycemia, respectively. Frequency of hypoglycemia and other related information were obtained by self-reporting or from medical records.
16.0% of participants were having IAH, 66.0% of participants reported recurrent hypoglycemia (>once/month) and 18.0% of participants developed ≥1 severe hypoglycemia during the previous year. IAH was not associated with age, gender, duration of DM, HbA1c, insulin regimen, adherence to insulin or development of severe hypoglycemia (p-values> 0.05). Instead, IAH was associated with frequency of hypoglycemia during the previous 6 months (p-value< 0.01). Hunger, tiredness, dizziness, drowsiness, inability to concentrate, trembling and weakness were the most common symptoms felt by participants when they develop hypoglycemia. Hunger was the only common symptom that was significantly higher in children compared to adolescent (p-value < 0.01).
This study has reported low prevalence of IAH in children and adolescents with Type 1 DM in North of Jordan. IAH was more common in subjects with more frequent hypoglycemia.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>31651281</pmid><doi>10.1186/s12902-019-0441-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9490-0979</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC endocrine disorders, 2019-10, Vol.19 (1), p.107-107, Article 107 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Adolescent Awareness Biomarkers - analysis Blood Glucose - analysis Blood Glucose Self-Monitoring Care and treatment Child Child, Preschool Children Complications and side effects Cross-Sectional Studies Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes research Diabetes therapy Diagnosis Female Follow-Up Studies Glycosylated hemoglobin Health Knowledge, Attitudes, Practice Humans Hypoglycemia Hypoglycemia - chemically induced Hypoglycemia - epidemiology Hypoglycemia - psychology Hypoglycemic Agents - adverse effects Insulin Jordan - epidemiology Juvenile diabetes Male Medical records Prevalence Prognosis Seizures (Medicine) Self care (Health) Type 1 diabetes |
| title | Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan |
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