Relationship between hypertensive disease stages of pregnancy and plateletcrit values: A retrospective cohort study

• Published in: Heliyon 2024-11, Vol.10 (22), p.e39991, Article e39991
• Main Authors: Sivas, Mustafa Can, Aslancan, Reyhan, Bayram, Taha Yasin
• Format: Article
• Language: English
• Subjects: Gestational hypertension; HELLP; Platelet count; Plateletcrit; Severe preeclampsia
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e39991

The aim of this study was to investigate the correlation between plateletcrit (PCT) and stages of hypertensive disease of pregnancy by comparing values in groups with healthy pregnancies, gestational hypertension [GHT], preeclampsia with proteinuria [PE + P] and severe preeclampsia with proteinuria [sPE + P]. The secondary aim was to investigate how proteinuria affects PCT values in these patients. This was a retrospective cohort study. Patients who had been hospitalized for labor were included in the study. The following groups were created: healthy pregnancies (n = 36), [GHT] (n = 36), [PE + P] (n = 36) and [sPE + P] (n = 36). PCT and platelet values from blood tests performed immediately after hospitalization were compared among the four groups. Additionally, the PCT and platelet values in the early pregnancy period of same patients were determined and compared. There were no statistically significant differences among the groups in terms of age, gravidity or parity (p > 0.05). The mean platelet counts of the groups ranged from 219,250/mm3 to 241,310/mm3. There were no significant differences among the groups (with or without proteinuria) in terms of the platelet counts or PCT values (p > 0.05). A reducing or enhancing effect of proteinuria on the PCT value was not observed. Additionally, based on data from the early weeks of pregnancy, there were no significant differences among the groups in terms of the platelet counts or PCT values (p > 0.05). PCT may not be appropriate to use for the diagnosis or prediction of sPE in patients whose platelet counts have not decreased. A normal PCT value should not be interpreted as the absence of progression to sPE. There is a need for new PCT and PE studies that take platelet counts into account and include women in the early weeks of pregnancy. •Study analyzed relationship between plateletcrit(PCT) and severe preeclampsia(sPE).•In sPE without a decrease in platelet count, there may be no difference in PCT.•A normal PCT should not be interpreted as the absence of progression to sPE.•No effect of proteinuria on PCT value was observed in hypertensive pregnant women.•This effect was analyzed for the first time in hypertensive diseases of pregnancy.