Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis reveale...

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Bibliographic Details
Published in:Metabolites 2021-12, Vol.11 (12), p.850
Main Authors: Legrand, Elena, Basu, Niladri, Hecker, Markus, Crump, Doug, Xia, Jianguo, Chandramouli, Bharat, Butler, Heather, Head, Jessica A
Format: Article
Language:English
Subjects:
avian
Benzo(a)pyrene
Biomarkers
Chemicals
Chlorpyrifos
Communication
Coturnix japonica
early life stage
Embryos
environmental metabolomics
Ethinylestradiol
Flame retardants
Fluoxetine
LC-MS
Lipid metabolism
Lipids
Liver
mass spectrometry
Metabolism
Metabolites
Metabolomics
Methionine
NMR
Nuclear magnetic resonance
Oxidative stress
Steroids
Trenbolone
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Summary:This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11120850