Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation - Is It Time to Test?

Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and...

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Bibliographic Details
Published in:Transplant international 2024-11, Vol.37, p.13280
Main Authors: Martin, Paul James Patrick, Willicombe, Michelle, Roufosse, Candice
Format: Article
Language:English
Subjects:
antibody mediated rejection
AT1R
AT1R antibody
Graft Rejection - immunology
Health Archive
Histocompatibility Testing - methods
Humans
Kidney Transplantation - adverse effects
non-HLA antibody
Organ Transplantation
Receptor, Angiotensin, Type 1 - immunology
rejection
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Summary:Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and refinement of recommendations for histocompatibility testing by the Sensitization in Transplantation Assessment of Risk (STAR) workgroup. This mini-review discusses the latest understanding of pathophysiological mechanisms, clinical evidence for the pathogenicity of AT1R-Ab, and methods of laboratory testing.
ISSN:1432-2277
0934-0874
1432-2277
DOI:10.3389/ti.2024.13280