The Complex Role of STAT3 in Viral Infections

Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies...

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Bibliographic Details
Published in:Journal of immunology research 2015-01, Vol.2015 (2015), p.1-9
Main Author: Kuchipudi, Suresh V.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Avian flu
Cytokines
Cytokines - metabolism
Deoxyribonucleic acid
DNA
Genes
Growth factors
Host-Pathogen Interactions
Humans
Immunity
Immunology
Infections
Janus Kinases - metabolism
Kinases
Pathogenesis
Phosphorylation
Protein Binding
Protein Interaction Domains and Motifs
Proteins
Review
Roles
Signal Transduction
STAT3 Transcription Factor - chemistry
STAT3 Transcription Factor - metabolism
Stem cells
Transcription factors
Viral infections
Virus Diseases - metabolism
Virus Diseases - virology
Virus Physiological Phenomena
Virus Replication
Viruses
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Summary:Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.
ISSN:2314-8861
2314-7156
DOI:10.1155/2015/272359