Viral Toxin NS1 Implication in Dengue Pathogenesis Making It a Pivotal Target in Development of Efficient Vaccine

The mosquito-borne viral disease dengue is a global public health problem causing a wide spectrum of clinical manifestations ranging from mild dengue fever to severe dengue with plasma leakage and bleeding which are often fatal. To date, there are no specific medications to treat dengue and prevent...

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Published in:Vaccines (Basel) 2021-08, Vol.9 (9), p.946
Main Authors: Lebeau, Grégorie, Lagrave, Alisé, Ogire, Eva, Grondin, Lauriane, Seriacaroupin, Soundary, Moutoussamy, Cédric, Mavingui, Patrick, Hoarau, Jean-Jacques, Roche, Marjolaine, Krejbich-Trotot, Pascale, Desprès, Philippe, Viranaicken, Wildriss
Format: Article
Language:English
Subjects:
Antibodies
Antigens
arbovirus
Cytokines
dengue
Dengue fever
Dengue hemorrhagic fever
Disease
Fever
Genomes
Hemorrhage
Immunopathogenesis
Infections
Life Sciences
Microbiology and Parasitology
NS1
Pathogenesis
Proteins
Public health
Review
Serotypes
Toxins
Vaccine development
Vaccines
Vector-borne diseases
Viral diseases
viral hemorrhagic fever
viral immunopathogenesis
viral toxin
Virology
West Nile virus
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description The mosquito-borne viral disease dengue is a global public health problem causing a wide spectrum of clinical manifestations ranging from mild dengue fever to severe dengue with plasma leakage and bleeding which are often fatal. To date, there are no specific medications to treat dengue and prevent the risk of hemorrhage. Dengue is caused by one of four genetically related but antigenically distinct serotypes DENV-1–DENV-4. The growing burden of the four DENV serotypes has intensified both basic and applied research to better understand dengue physiopathology. Research has shown that the secreted soluble hexameric form of DENV nonstructural protein-1 (sNS1) plays a significant role in the pathogenesis of severe dengue. Here, we provide an overview of the current knowledge about the role of sNS1 in the immunopathogenesis of dengue disease. We discuss the potential use of sNS1 in future vaccine development and its potential to improve dengue vaccine efficiency, particularly against severe dengue illness.
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subjects Antibodies
Antigens
arbovirus
Cytokines
dengue
Dengue fever
Dengue hemorrhagic fever
Disease
Fever
Genomes
Hemorrhage
Immunopathogenesis
Infections
Life Sciences
Microbiology and Parasitology
NS1
Pathogenesis
Proteins
Public health
Review
Serotypes
Toxins
Vaccine development
Vaccines
Vector-borne diseases
Viral diseases
viral hemorrhagic fever
viral immunopathogenesis
viral toxin
Virology
West Nile virus
title Viral Toxin NS1 Implication in Dengue Pathogenesis Making It a Pivotal Target in Development of Efficient Vaccine
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