Extracellular Vesicles' Role in Angiogenesis and Altering Angiogenic Signaling

Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial mediators in intercellular communication and have gai...

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Bibliographic Details
Published in:Medical sciences (Basel) 2024-01, Vol.12 (1), p.4
Main Authors: Ateeq, Maryam, Broadwin, Mark, Sellke, Frank W, Abid, M Ruhul
Format: Article
Language:English
Subjects:
Angiogenesis
angiogenic signaling
apoptotic bodies
Biosynthesis
Blood vessels
Cardiovascular Physiological Phenomena
Cell Communication
Cells
Communication
exosomes
Extracellular Vesicles
Heat shock proteins
Ligands
Lipids
MicroRNAs
microvesicles
Physiology
Plasma
Review
Signal Transduction
Tumorigenesis
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Summary:Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial mediators in intercellular communication and have gained significant attention for their role in modulating angiogenic processes. This review explores the multifaceted role of EVs in angiogenesis and their capacity to modulate angiogenic signaling pathways. Through comprehensive analysis of a vast body of literature, this review highlights the potential of utilizing EVs as therapeutic tools to modulate angiogenesis for both physiological and pathological purposes. A good understanding of these concepts holds promise for the development of novel therapeutic interventions targeting angiogenesis-related disorders.
ISSN:2076-3271
2076-3271
DOI:10.3390/medsci12010004