Impact of tricuspid regurgitation on survival in patients with cardiac amyloidosis

• Published in: ESC Heart Failure 2021-02, Vol.8 (1), p.438-446
• Main Authors: Fagot, Jerome, Lavie‐Badie, Yoan, Blanchard, Virginie, Fournier, Pauline, Galinier, Michel, Carrié, Didier, Lairez, Olivier, Cariou, Eve, Alric, Laurent, Bureau, Christophe, Chauveau, Dominique, Cintas, Pascal, Colombat, Magali, Delas, Audrey, Dupin‐Deguine, Delphine, Faguer, Stanislas, Huart, Antoine, Puissant, Bénédicte, Pugnet, Grégory, Prévot, Grégoire, Ribes, David, Roussel, Murielle, Sailler, Laurent
• Format: Article
• Language: English
• Subjects: Amyloid Neuropathies, Familial; Amyloidosis; Body mass index; Cardiac amyloidosis; Cardiovascular disease; Diabetes; Echocardiography; Humans; Light‐chain amyloidosis; Mortality; Original; Original s; Patients; Peptides; Population; Prognosis; Pulmonary arteries; Pulmonary hypertension; Regression analysis; Scintigraphy; Software; Statistical analysis; Stroke Volume; Survival analysis; Transthyretin amyloidosis; Tricuspid regurgitation; Tricuspid Valve Insufficiency; Ventricular Function, Left
• ISSN: 2055-5822; 2055-5822
• DOI: 10.1002/ehf2.13093

Aims Tricuspid regurgitation (TR) is a common finding and has been associated with poorer outcome in patients with heart failure. This study sought to investigate the prognostic value of TR in patients with cardiac amyloidosis (CA). Methods and results Two‐hundred and eighty‐three patients with CA—172 (61%) wild‐type transthyretin amyloidosis (ATTRwt) and 111 (39%) light‐chain amyloidosis (AL)—were consecutively enrolled between December 2010 and September 2019. Transthoracic echocardiographies at time of diagnosis were reviewed to establish the presence and severity of TR and its relationship with all‐cause mortality during patients' follow‐up. Seventy‐four (26%) patients had a moderate‐to‐severe TR. Moderate‐to‐severe TR was associated with New York Heart Association status (P