The diagnostic role of serum inflammatory and soluble proteins on dementia subtypes: correlation with cognitive and functional decline

In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer's disease (AD), vascular dementia...

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Bibliographic Details
Published in:Behavioural neurology 2007, Vol.18 (4), p.207-215
Main Authors: Oztürk, Candan, Ozge, Aynur, Yalin, Osman Ozgür, Yilmaz, I Arda, Delialioglu, Nuran, Yildiz, Cilem, Tesdelen, Bahar, Kudiaki, Cigdem
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - analysis
Acute-Phase Proteins - immunology
Aged
Amyloid beta-Peptides - blood
Amyloid beta-Peptides - immunology
Analysis of Variance
Biomarkers - blood
Case-Control Studies
Cognition Disorders - blood
Cognition Disorders - classification
Cognition Disorders - diagnosis
Cognition Disorders - immunology
Cross-Sectional Studies
Dementia - blood
Dementia - classification
Dementia - diagnosis
Dementia - immunology
Diagnosis, Differential
Female
Humans
Interleukins - blood
Interleukins - classification
Male
Matched-Pair Analysis
Middle Aged
Peptide Fragments - blood
Peptide Fragments - immunology
Reference Values
Severity of Illness Index
Statistics, Nonparametric
Tumor Necrosis Factor-alpha - blood
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Summary:In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer's disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1beta, IL-2, IL-6, IL-18, TNF-alpha, beta-Amlyloid 1-40 and alpha1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of alpha1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1beta and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.
ISSN:0953-4180
1875-8584
DOI:10.1155/2007/432190