The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines

The relative biological effectiveness (RBE) calculations used during the planning of ion therapy treatments are generally based on the microdosimetric kinetic model (MKM) and the local effect model (LEM). The Mayo Clinic Florida MKM (MCF MKM) was recently developed to overcome the limitations of pre...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (20), p.12491
Main Authors: Parisi, Alessio, Beltran, Chris J, Furutani, Keith M
Format: Article
Language:English
Subjects:
Animals
Biological effects
Cell Line
Cell lines
Chromosomes
clonogenic survival
Deoxyribonucleic acid
DNA
Florida
Humans
Kinetics
MCF MKM
microdosimetry
particle therapy
PHITS
Radiation
Relative Biological Effectiveness
Relative biological effectiveness (RBE)
Reproduction (biology)
Rodentia
Survival
X-rays
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Summary:The relative biological effectiveness (RBE) calculations used during the planning of ion therapy treatments are generally based on the microdosimetric kinetic model (MKM) and the local effect model (LEM). The Mayo Clinic Florida MKM (MCF MKM) was recently developed to overcome the limitations of previous MKMs in reproducing the biological data and to eliminate the need for ion-exposed in vitro data as input for the model calculations. Since we are considering to implement the MCF MKM in clinic, this article presents (a) an extensive benchmark of the MCF MKM predictions against corresponding in vitro clonogenic survival data for 4 rodent and 10 cell lines exposed to ions from H to U, and (b) a systematic comparison with published results of the latest version of the LEM (LEM IV). Additionally, we introduce a novel approach to derive an approximate value of the MCF MKM model parameters by knowing only the animal species and the mean number of chromosomes. The overall good agreement between MCF MKM predictions and in vitro data suggests the MCF MKM can be reliably used for the RBE calculations. In most cases, a reasonable agreement was found between the MCF MKM and the LEM IV.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232012491