Fabrication and properties of interweaved poly(ether ether ketone) composite scaffolds

This paper interweaved scaffolds with poly(ether ether ketone) (PEEK) and poly(lactic acid)/Walnut shell/hydroxypatite (PLA/WS/HA) composites by using fused filament fabrication technology, although there was a huge difference in thermal property term between PLA and PEEK. In order to keep mechanica...

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Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.22193-17, Article 22193
Main Authors: Song, Xiaohui, Shi, Dengwen, Li, Wenqiang, Qin, Huadong, Han, Xingguo
Format: Article
Language:English
Subjects:
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Cell proliferation
Compression
Cytotoxicity
Ether
Ethers
Ethyl Ethers
Fabrication
Fractures
Humanities and Social Sciences
Ketones
Materials Testing
Mechanical properties
multidisciplinary
Polyesters
Polylactic acid
Pores
Science
Science (multidisciplinary)
Strain
Thermal stability
Tissue engineering
Tissue Scaffolds
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Summary:This paper interweaved scaffolds with poly(ether ether ketone) (PEEK) and poly(lactic acid)/Walnut shell/hydroxypatite (PLA/WS/HA) composites by using fused filament fabrication technology, although there was a huge difference in thermal property term between PLA and PEEK. In order to keep mechanical properties of PEEK scaffold and remedy the stress loss produced by pores, PLA/WS/HA composites were used to fill the pores with gradient form outside-in (0.4-0.8 mm, 0.6-1.0 mm, 0.8-1.2 mm and 1.6-2.0 mm). The thermal stability, tensile and compression properties, tensile fracture surface morphology, cytotoxicity and in vivo experiment were investigated. The results showed: the scaffolds were intact without any flashes and surface destruction, and kept a well thermal stability. Compared with the PEEK porous scaffolds, the tensile fracture stress and strain, compression yield stress and strain of interweaved scaffolds were dramatically enhanced by 24.1%, 438%, 359.1% and 921.2%, respectively, and they climbed to the climax at 8 wt% of WS. In vivo experiment showed that the degradation of PLA/WS/HA composites synchronized with the adhesion, proliferation and ingrowth of bone cells, keeping the stable biomechanical properties of interweaved scaffolds. Those experiments showed that interweaved PEEK-PLA/WS/HA scaffolds had the potential to be used as bone implant in tissue engineering.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-26736-4