Ventilatory constraint is more severe in walking than cycling in patients with COPD

Due to its effectivity in assessing functional capacity and adding prognostic information to the staging of chronic obstructive pulmonary disease (COPD) patients, the 6-min walk test (6MWT) is extensively used in clinical evaluation. Currently, there is little information about the physiological res...

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Bibliographic Details
Published in:Current research in physiology 2021-01, Vol.4, p.73-79
Main Authors: Chlumský, Jan, Zindr, Ondřej
Format: Article
Language:English
Subjects:
COPD
Dynamic hyperinflation
Exercise
Research Paper
V/Q mismatch
Ventilatory response
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Summary:Due to its effectivity in assessing functional capacity and adding prognostic information to the staging of chronic obstructive pulmonary disease (COPD) patients, the 6-min walk test (6MWT) is extensively used in clinical evaluation. Currently, there is little information about the physiological response this test elicits in patients, especially when compared to cardiopulmonary exercise test (CPET). The aim of the study was to compare ventilatory and metabolic responses between these tests commonly used for the assessment of clinical outcome. A group of 20 patients with moderate to very severe COPD were tested for their pulmonary function (flow-volume curve, static lung volumes), occlusion mouth pressures and breath-by-breath measurement of flow, volumes, and oxygen (O2) and carbon dioxide (CO2) concentration during the 6MWT and CPET. All parameters measured during both exercise tests were assessed over the throughout of the tests and compared between each other at specified time points. Serially measured inspiratory vital capacity (IVC) decreased more rapidly and extensively during the walk-test (p ​
ISSN:2665-9441
2665-9441
DOI:10.1016/j.crphys.2021.02.004