The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence

is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, infections are associated with post-infection sequelae in developed countries and malnutrition...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-01, Vol.13 (1), p.135
Main Authors: Gabbert, Amber D, Mydosh, Jennifer L, Talukdar, Prabhat K, Gloss, Lisa M, McDermott, Jason E, Cooper, Kerry K, Clair, Geremy C, Konkel, Michael E
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Animals
Antibiotics
Antimicrobial agents
Asymptomatic
Bacteria
bacteria-host cell interactions
Bacterial Proteins - metabolism
BASIC BIOLOGICAL SCIENCES
Campylobacter
Campylobacter Infections - metabolism
Campylobacter Infections - microbiology
Campylobacter jejuni
Campylobacter jejuni - metabolism
Campylobacteriosis
Cattle
Cell interactions
Cell survival
Complications
Diarrhea
Disease
effectors
Epidemics
Fecal incontinence
Flagella
Food contamination & poisoning
Gastroenteritis
Guillain-Barre syndrome
Humans
Illnesses
Infections
Inflammation
Malnutrition
Motility
Pathogens
Poultry
Review
Secretion
Stainless steel
type III secretion system
type IV secretion system
type VI secretion system
Virulence
Virulence Factors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, infections are associated with post-infection sequelae in developed countries and malnutrition and growth-stunting in low- and middle-income countries. Despite the increasing prevalence of the disease, campylobacteriosis, and the recognition that this pathogen is a serious health threat, our understanding of pathogenesis remains incomplete. In this review, we focus on the secretion systems proposed to contribute to host-cell interactions and survival in the host. Moreover, we have applied a genomics approach to defining the structural and mechanistic features of type III, IV, and VI secretion systems. Special attention is focused on the flagellar type III secretion system and the prediction of putative effectors, given that the proteins exported via this system are essential for host cell invasion and the inflammatory response. We conclude that does not possess a type IV secretion system and relies on the type III and type VI secretion systems to establish a niche and potentiate disease.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13010135