Using the Systems Biology Approach and Molecular Method to Investigate the Role of the Dopaminergic Pathway in Osteoarthritis: A Case Control Study

Osteoarthritis is the most common type of arthritis and one of the leading causes of job loss and motor disabilities. Recently, the involvement of dopaminergic pathways and dopamine receptor genes has been considered in this disease. Therefore, studying and comparing the expression pattern of these...

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Bibliographic Details
Published in:Clinical interventions in aging 2020-01, Vol.15, p.321-327
Main Authors: Sheikhpour, Mojgan, Eliaspour, Darioush, Arabi, Iraj, Raeissadat, Seyed Ahmad, Lari, Arezou, Seif Barghi, Tohid
Format: Article
Language:English
Subjects:
Arthritis
Biochemistry
Cartilage
Case-Control Studies
Data analysis
Disabilities
Diseases
Dopamine
Dopamine - metabolism
dopamine receptor genes
Dopamine receptors
Female
Gene expression
Genes
Humans
Immune system
Infectious diseases
Lymphocytes
Male
Medical research
Methods
Molecular biology
Nervous system
Neurotransmitters
Original Research
Osteoarthritis
Osteoarthritis - metabolism
Pain
Patients
Phenols (Class of compounds)
Proteins
Receptors, Dopamine - metabolism
Receptors, Dopamine D2 - metabolism
Rheumatoid arthritis
Serotonin
Software
Statistical analysis
Systems Biology
Time
Transcriptome
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Summary:Osteoarthritis is the most common type of arthritis and one of the leading causes of job loss and motor disabilities. Recently, the involvement of dopaminergic pathways and dopamine receptor genes has been considered in this disease. Therefore, studying and comparing the expression pattern of these receptor genes can lead to a greater understanding of the pathogenesis of this disease. In this research, we used the systems biology approach to investigate the role of the dopaminergic pathway in osteoarthritis. Then the gene expression pattern of dopamine receptor genes was examined in an osteoarthritis patientgroup in comparison with healthy individuals by Real-time PCR method. The analysis of the transcriptome dataset of osteoarthritis identified some genes in the dopaminergic pathway and the six most important genes in this disease are in the network with a significant relationship to dopamine receptors which differentially expressed compared to health groups. Statistical analysis of the case control study showed a significant difference (P-value
ISSN:1178-1998
1176-9092
1178-1998
DOI:10.2147/CIA.S238351