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Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

, an aquatic plant, is used as folk medicine in some countries. Our previous study demonstrated that the methanol extract of inhibited the activity of tyrosinases, tyrosine related protein (TRP)1 and TRP2, and microphthalmia-associated transcription factor, as well as the activity of protein kinase...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2018-09, Vol.23 (9), p.2342
Main Authors: Kim, You Ah, Kim, Dong Hee, Park, Chae Bin, Park, Tae Soon, Park, Byoung Jun
Format: Article
Language:English
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Summary:, an aquatic plant, is used as folk medicine in some countries. Our previous study demonstrated that the methanol extract of inhibited the activity of tyrosinases, tyrosine related protein (TRP)1 and TRP2, and microphthalmia-associated transcription factor, as well as the activity of protein kinase A, by effectively inhibiting cyclic adenosine monophosphate. Although the biological activities of extract have been reported, there are no reports on the skin bioactivity of the main compound(s) on human keratinocytes. This study investigated the anti-inflammatory and moisturizing effects of quercetin 3,7-dimethyl ether 4'-glucoside (QDG) isolated from . In brief, ultraviolet B irradiated keratinocytes were pretreated with different concentrations of QDG, and the effects of QDG on various inflammatory markers were determined. QDG significantly inhibited inflammation-related cytokines and chemokines and enhanced the activation of skin barrier factors. Additionally, QDG also attenuated phosphorylation inhibition of the upstream cytokines and nuclear factor-κB expression. These results suggest that QDG isolated from may serve as a potential source of bioactive substances for chronic inflammatory skin diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23092342