Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention

• Published in: Platelets (Edinburgh) 2021-05, Vol.32 (4), p.555-559
• Main Authors: Sumaya, Wael, Parker, William A.E., Judge, Heather M., Hall, Ian R., Orme, Rachel C., Adam, Zulfiquar, Richardson, James D., Rothman, Alexander M.K., Morgan, Kenneth P., Gunn, Julian P., Storey, Robert F.
• Format: Article
• Language: English
• Subjects: Enoxaparin; Enoxaparin - pharmacology; Enoxaparin - therapeutic use; Feasibility Studies; Female; Fibrinolytic Agents - pharmacology; Fibrinolytic Agents - therapeutic use; glycoprotein IIb/IIIa inhibitors; Humans; inhibitor; Male; Opiate Alkaloids - pharmacology; Opiate Alkaloids - therapeutic use; P2Y; p2y12 inhibitor; Percutaneous Coronary Intervention - methods; primary percutaneous coronary intervention; ST-ELEVATION myocardial infarction; unfractionated heparin
• ISSN: 0953-7104; 1369-1635
• DOI: 10.1080/09537104.2020.1779925

A novel enoxaparin regimen consisting of intra-arterial bolus (0.75 mg/kg) followed by intravenous infusion (0.75 mg/kg/6 hours) has been developed as a possible solution to the delayed absorption of oral P2Y 12 inhibitors in opiate-treated ST-elevation myocardial infarction (STEMI) patients undergoing primary angioplasty. We aimed to study the feasibility of this regimen as an alternative to standard-of-care treatment (SOC) with unfractionated heparin ± glycoprotein IIb/IIIa antagonist (GPI). One hundred opiate-treated patients presenting with STEMI and accepted for primary angioplasty were randomized (1:1) to either enoxaparin or SOC. Fifty patients were allocated enoxaparin (median age 61, 40% females) and 49 allocated SOC (median age 62, 22% females). One developed stroke before angiography and was withdrawn. One SOC patient had a gastrointestinal bleed resulting in 1 g drop in hemoglobin and early cessation of GPI infusion. Two enoxaparin patients had transient minor bleeding: one transient gingival bleed and one episode of coffee ground vomit with no hemoglobin drop or hemodynamic instability. Two SOC and no enoxaparin group patients had acute stent thrombosis. These preliminary data support further study of this novel 6-hour enoxaparin regimen in opiate-treated PPCI patients.