Introduction of Carbonyl Groups into Antibodies

Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-12, Vol.28 (23), p.7890
Main Authors: Gulyak, Evgeny L, Alferova, Vera A, Korshun, Vladimir A, Sapozhnikova, Ksenia A
Format: Article
Language:English
Subjects:
ADC
Aldehydes
Amino acids
Antibodies
Antigen-antibody reactions
Antigens
Biological products
Carbohydrates
carbonyl groups
Chemical bonds
Drug delivery systems
Drugs
FDA approval
Genetic engineering
Health aspects
Localization
Monoclonal antibodies
Oxidation
oxime ligation
periodate oxidation
Polypeptides
UAAs
Vehicles
Viral antibodies
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Summary:Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic agents, including antibody-drug conjugates (ADCs). To meet this challenge, it is imperative to advance methods for modifying antibodies. A particularly promising strategy involves the introduction of carbonyl groups into the antibody that are amenable to further modification by biorthogonal reactions, namely aliphatic, aromatic, and α-oxo aldehydes, as well as aliphatic and aryl-alkyl ketones. In this review, we summarize the preparation methods and applications of site-specific antibody conjugates that are synthesized using this approach.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28237890