Introduction of Carbonyl Groups into Antibodies

Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-12, Vol.28 (23), p.7890
Main Authors: Gulyak, Evgeny L, Alferova, Vera A, Korshun, Vladimir A, Sapozhnikova, Ksenia A
Format: Article
Language:English
Subjects:
ADC
Aldehydes
Amino acids
Antibodies
Antigen-antibody reactions
Antigens
Antineoplastic Agents - therapeutic use
Biological products
Carbohydrates
carbonyl groups
Chemical bonds
Drug Delivery Systems
Drugs
FDA approval
Genetic engineering
Health aspects
Immunoconjugates - therapeutic use
Localization
Monoclonal antibodies
Oxidation
oxime ligation
periodate oxidation
Polypeptides
UAAs
Vehicles
Viral antibodies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3
cites cdi_FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3
container_end_page
container_issue 23
container_start_page 7890
container_title Molecules (Basel, Switzerland)
container_volume 28
creator Gulyak, Evgeny L
Alferova, Vera A
Korshun, Vladimir A
Sapozhnikova, Ksenia A
description Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic agents, including antibody-drug conjugates (ADCs). To meet this challenge, it is imperative to advance methods for modifying antibodies. A particularly promising strategy involves the introduction of carbonyl groups into the antibody that are amenable to further modification by biorthogonal reactions, namely aliphatic, aromatic, and α-oxo aldehydes, as well as aliphatic and aryl-alkyl ketones. In this review, we summarize the preparation methods and applications of site-specific antibody conjugates that are synthesized using this approach.
doi_str_mv 10.3390/molecules28237890
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_335877803aae41978d5a31dffbb0cf66</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A775891389</galeid><doaj_id>oai_doaj_org_article_335877803aae41978d5a31dffbb0cf66</doaj_id><sourcerecordid>A775891389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3</originalsourceid><addsrcrecordid>eNptkctuFDEQRS0EIiHwAWxQS2zYTGK72m17ORqFMFIkNrC23H5EHnW7Brt7kb_HYUJ4youySudeV_kS8pbRSwBNr2acglunULniIJWmz8g56zndAO3189_uZ-RVrQdKOeuZeEnOQNFBDkydk6t9Xgr61S0Jc4ex29kyYr6fupuC67F2KS_YbfOSRvQp1NfkRbRTDW8e6wX5-vH6y-7T5vbzzX63vd04QcWyiaLVASKIkQuvQUrnRFTRAUjXOz30I-cQqBAuCOucH2KkYwAroQ2tIlyQ_cnXoz2YY0mzLfcGbTI_GljujC1LclMwAEJJqShYG3qmpfLCAvMxjiN1cRia14eT17HgtzXUxcypujBNNgdcq-Gact0DF7yh7_9CD7iW3DY1XGndfk9J9ou6s-39lCMuxboHU7OVUijNQOlGXf6HaseHOTnMIabW_0PATgJXsNYS4tPejJqHwM0_gTfNu8eB13EO_knxM2H4Dus_pWA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2899415871</pqid></control><display><type>article</type><title>Introduction of Carbonyl Groups into Antibodies</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><creator>Gulyak, Evgeny L ; Alferova, Vera A ; Korshun, Vladimir A ; Sapozhnikova, Ksenia A</creator><creatorcontrib>Gulyak, Evgeny L ; Alferova, Vera A ; Korshun, Vladimir A ; Sapozhnikova, Ksenia A</creatorcontrib><description>Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic agents, including antibody-drug conjugates (ADCs). To meet this challenge, it is imperative to advance methods for modifying antibodies. A particularly promising strategy involves the introduction of carbonyl groups into the antibody that are amenable to further modification by biorthogonal reactions, namely aliphatic, aromatic, and α-oxo aldehydes, as well as aliphatic and aryl-alkyl ketones. In this review, we summarize the preparation methods and applications of site-specific antibody conjugates that are synthesized using this approach.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules28237890</identifier><identifier>PMID: 38067618</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>ADC ; Aldehydes ; Amino acids ; Antibodies ; Antigen-antibody reactions ; Antigens ; Antineoplastic Agents - therapeutic use ; Biological products ; Carbohydrates ; carbonyl groups ; Chemical bonds ; Drug Delivery Systems ; Drugs ; FDA approval ; Genetic engineering ; Health aspects ; Immunoconjugates - therapeutic use ; Localization ; Monoclonal antibodies ; Oxidation ; oxime ligation ; periodate oxidation ; Polypeptides ; UAAs ; Vehicles ; Viral antibodies</subject><ispartof>Molecules (Basel, Switzerland), 2023-12, Vol.28 (23), p.7890</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3</citedby><cites>FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3</cites><orcidid>0000-0002-8961-5890 ; 0000-0001-5847-7766 ; 0000-0001-9436-6561</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2899415871/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2899415871?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38067618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gulyak, Evgeny L</creatorcontrib><creatorcontrib>Alferova, Vera A</creatorcontrib><creatorcontrib>Korshun, Vladimir A</creatorcontrib><creatorcontrib>Sapozhnikova, Ksenia A</creatorcontrib><title>Introduction of Carbonyl Groups into Antibodies</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic agents, including antibody-drug conjugates (ADCs). To meet this challenge, it is imperative to advance methods for modifying antibodies. A particularly promising strategy involves the introduction of carbonyl groups into the antibody that are amenable to further modification by biorthogonal reactions, namely aliphatic, aromatic, and α-oxo aldehydes, as well as aliphatic and aryl-alkyl ketones. In this review, we summarize the preparation methods and applications of site-specific antibody conjugates that are synthesized using this approach.</description><subject>ADC</subject><subject>Aldehydes</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Antigen-antibody reactions</subject><subject>Antigens</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological products</subject><subject>Carbohydrates</subject><subject>carbonyl groups</subject><subject>Chemical bonds</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>FDA approval</subject><subject>Genetic engineering</subject><subject>Health aspects</subject><subject>Immunoconjugates - therapeutic use</subject><subject>Localization</subject><subject>Monoclonal antibodies</subject><subject>Oxidation</subject><subject>oxime ligation</subject><subject>periodate oxidation</subject><subject>Polypeptides</subject><subject>UAAs</subject><subject>Vehicles</subject><subject>Viral antibodies</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkctuFDEQRS0EIiHwAWxQS2zYTGK72m17ORqFMFIkNrC23H5EHnW7Brt7kb_HYUJ4youySudeV_kS8pbRSwBNr2acglunULniIJWmz8g56zndAO3189_uZ-RVrQdKOeuZeEnOQNFBDkydk6t9Xgr61S0Jc4ex29kyYr6fupuC67F2KS_YbfOSRvQp1NfkRbRTDW8e6wX5-vH6y-7T5vbzzX63vd04QcWyiaLVASKIkQuvQUrnRFTRAUjXOz30I-cQqBAuCOucH2KkYwAroQ2tIlyQ_cnXoz2YY0mzLfcGbTI_GljujC1LclMwAEJJqShYG3qmpfLCAvMxjiN1cRia14eT17HgtzXUxcypujBNNgdcq-Gact0DF7yh7_9CD7iW3DY1XGndfk9J9ou6s-39lCMuxboHU7OVUijNQOlGXf6HaseHOTnMIabW_0PATgJXsNYS4tPejJqHwM0_gTfNu8eB13EO_knxM2H4Dus_pWA</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Gulyak, Evgeny L</creator><creator>Alferova, Vera A</creator><creator>Korshun, Vladimir A</creator><creator>Sapozhnikova, Ksenia A</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8961-5890</orcidid><orcidid>https://orcid.org/0000-0001-5847-7766</orcidid><orcidid>https://orcid.org/0000-0001-9436-6561</orcidid></search><sort><creationdate>20231201</creationdate><title>Introduction of Carbonyl Groups into Antibodies</title><author>Gulyak, Evgeny L ; Alferova, Vera A ; Korshun, Vladimir A ; Sapozhnikova, Ksenia A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ADC</topic><topic>Aldehydes</topic><topic>Amino acids</topic><topic>Antibodies</topic><topic>Antigen-antibody reactions</topic><topic>Antigens</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological products</topic><topic>Carbohydrates</topic><topic>carbonyl groups</topic><topic>Chemical bonds</topic><topic>Drug Delivery Systems</topic><topic>Drugs</topic><topic>FDA approval</topic><topic>Genetic engineering</topic><topic>Health aspects</topic><topic>Immunoconjugates - therapeutic use</topic><topic>Localization</topic><topic>Monoclonal antibodies</topic><topic>Oxidation</topic><topic>oxime ligation</topic><topic>periodate oxidation</topic><topic>Polypeptides</topic><topic>UAAs</topic><topic>Vehicles</topic><topic>Viral antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gulyak, Evgeny L</creatorcontrib><creatorcontrib>Alferova, Vera A</creatorcontrib><creatorcontrib>Korshun, Vladimir A</creatorcontrib><creatorcontrib>Sapozhnikova, Ksenia A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Directory of Open Access Journals (Open Access)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gulyak, Evgeny L</au><au>Alferova, Vera A</au><au>Korshun, Vladimir A</au><au>Sapozhnikova, Ksenia A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Introduction of Carbonyl Groups into Antibodies</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>28</volume><issue>23</issue><spage>7890</spage><pages>7890-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecular diagnostic tools and antibody-based therapeutic agents, including antibody-drug conjugates (ADCs). To meet this challenge, it is imperative to advance methods for modifying antibodies. A particularly promising strategy involves the introduction of carbonyl groups into the antibody that are amenable to further modification by biorthogonal reactions, namely aliphatic, aromatic, and α-oxo aldehydes, as well as aliphatic and aryl-alkyl ketones. In this review, we summarize the preparation methods and applications of site-specific antibody conjugates that are synthesized using this approach.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38067618</pmid><doi>10.3390/molecules28237890</doi><orcidid>https://orcid.org/0000-0002-8961-5890</orcidid><orcidid>https://orcid.org/0000-0001-5847-7766</orcidid><orcidid>https://orcid.org/0000-0001-9436-6561</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1420-3049
ispartof Molecules (Basel, Switzerland), 2023-12, Vol.28 (23), p.7890
issn 1420-3049
1420-3049
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_335877803aae41978d5a31dffbb0cf66
source Open Access: PubMed Central; Publicly Available Content Database (Proquest) (PQ_SDU_P3)
subjects ADC
Aldehydes
Amino acids
Antibodies
Antigen-antibody reactions
Antigens
Antineoplastic Agents - therapeutic use
Biological products
Carbohydrates
carbonyl groups
Chemical bonds
Drug Delivery Systems
Drugs
FDA approval
Genetic engineering
Health aspects
Immunoconjugates - therapeutic use
Localization
Monoclonal antibodies
Oxidation
oxime ligation
periodate oxidation
Polypeptides
UAAs
Vehicles
Viral antibodies
title Introduction of Carbonyl Groups into Antibodies
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T18%3A00%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Introduction%20of%20Carbonyl%20Groups%20into%20Antibodies&rft.jtitle=Molecules%20(Basel,%20Switzerland)&rft.au=Gulyak,%20Evgeny%20L&rft.date=2023-12-01&rft.volume=28&rft.issue=23&rft.spage=7890&rft.pages=7890-&rft.issn=1420-3049&rft.eissn=1420-3049&rft_id=info:doi/10.3390/molecules28237890&rft_dat=%3Cgale_doaj_%3EA775891389%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c505t-f5c5063f35b25d9377cc5f8fc337c4c964b223e055ce5accd6ff0be3a731428f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2899415871&rft_id=info:pmid/38067618&rft_galeid=A775891389&rfr_iscdi=true