CD4+ T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy

The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8+ T cells because of their cytotoxic effector function; however, CD4+ T cells are crucial in the proper dev...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-05, Vol.10 (5), p.1114
Main Authors: Buschow, Sonja I., Jansen, Diahann T. S. L.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
CD4 antigen
CD4+ T cells
CD8 antigen
Chronic infection
Cytokines
Cytotoxicity
Effector cells
Hepatitis B
hepatitis B virus
Immune system
Immunotherapy
Infections
Liver diseases
Lymphocytes
Lymphocytes T
Pathogens
Review
T cell receptors
Viral infections
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Summary:The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8+ T cells because of their cytotoxic effector function; however, CD4+ T cells are crucial in the proper development of these long-lasting effector CD8+ T cells. In this review, we summarize what is known about CD4+ T cells in chronic HBV infection and discuss the importance and opportunities of including CD4+ T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10051114