Whole gland versus partial gland ablation in patients with localized prostate cancer treated by high-intensity focused ultrasound ablation

• Published in: Prostate international 2024-12, Vol.12 (4), p.213-218
• Main Authors: Lee, Hae Sung, Song, Sang Hun, Lee, Hakmin, Hong, Sung Kyu
• Format: Article
• Language: English
• Subjects: High-intensity focused ultrasound ablation; Partial gland ablation; Whole gland ablation
• ISSN: 2287-8882; 2287-903X
• DOI: 10.1016/j.prnil.2024.09.001

Focal therapy is considered one of the treatment options for localized prostate cancer (PCa), particularly for low or very-low-risk patients. In this study, we compared the mid-term oncological outcomes in localized PCa patients treated with high-intensity focused ultrasound (HIFU). We retrospectively analyzed 237 patients who underwent HIFU for localized PCa. Patients were divided into two groups based on ablation type: whole gland ablation (WGA) and partial gland ablation (PGA). Follow-up biopsies were performed after one year postoperatively, and the oncological outcomes were compared between the groups. Among the total of 237 patients, 54 subjects were treated by WGA and 183 subjects by PGA. After one year postoperatively, follow-up biopsies were conducted on 199 patients, revealing residual cancer in 21.4% of WGA group and 15.3% of PGA group. Additionally, clinically significant (CS) cancer was observed in 14.3% of WGA group and 8.3% of PGA group. Survival analyses revealed significantly longer failure-free (P