Whole gland versus partial gland ablation in patients with localized prostate cancer treated by high-intensity focused ultrasound ablation

Focal therapy is considered one of the treatment options for localized prostate cancer (PCa), particularly for low or very-low-risk patients. In this study, we compared the mid-term oncological outcomes in localized PCa patients treated with high-intensity focused ultrasound (HIFU). We retrospective...

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Published in:Prostate international 2024-12, Vol.12 (4), p.213-218
Main Authors: Lee, Hae Sung, Song, Sang Hun, Lee, Hakmin, Hong, Sung Kyu
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Language:English
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High-intensity focused ultrasound ablation
Partial gland ablation
Whole gland ablation
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Song, Sang Hun
Lee, Hakmin
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description Focal therapy is considered one of the treatment options for localized prostate cancer (PCa), particularly for low or very-low-risk patients. In this study, we compared the mid-term oncological outcomes in localized PCa patients treated with high-intensity focused ultrasound (HIFU). We retrospectively analyzed 237 patients who underwent HIFU for localized PCa. Patients were divided into two groups based on ablation type: whole gland ablation (WGA) and partial gland ablation (PGA). Follow-up biopsies were performed after one year postoperatively, and the oncological outcomes were compared between the groups. Among the total of 237 patients, 54 subjects were treated by WGA and 183 subjects by PGA. After one year postoperatively, follow-up biopsies were conducted on 199 patients, revealing residual cancer in 21.4% of WGA group and 15.3% of PGA group. Additionally, clinically significant (CS) cancer was observed in 14.3% of WGA group and 8.3% of PGA group. Survival analyses revealed significantly longer failure-free (P 
doi_str_mv 10.1016/j.prnil.2024.09.001
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In this study, we compared the mid-term oncological outcomes in localized PCa patients treated with high-intensity focused ultrasound (HIFU). We retrospectively analyzed 237 patients who underwent HIFU for localized PCa. Patients were divided into two groups based on ablation type: whole gland ablation (WGA) and partial gland ablation (PGA). Follow-up biopsies were performed after one year postoperatively, and the oncological outcomes were compared between the groups. Among the total of 237 patients, 54 subjects were treated by WGA and 183 subjects by PGA. After one year postoperatively, follow-up biopsies were conducted on 199 patients, revealing residual cancer in 21.4% of WGA group and 15.3% of PGA group. Additionally, clinically significant (CS) cancer was observed in 14.3% of WGA group and 8.3% of PGA group. Survival analyses revealed significantly longer failure-free (P &lt; 0.001) and salvage-free survival (P &lt; 0.001) in WGA group than in PGA group. Similarly, in the intermediate—high risk group, WGA group exhibited longer failure-free (P = 0.005) and salvage-free survival (P &lt; 0.001). HIFU was performed with acceptable oncological outcomes in localized PCa. Despite higher proportion of high-risk patients in WGA group, WGA was associated with significantly better failure-free survival and salvage-free survival. Further prospective and multi-center studies are warranted.</description><identifier>ISSN: 2287-8882</identifier><identifier>EISSN: 2287-903X</identifier><identifier>DOI: 10.1016/j.prnil.2024.09.001</identifier><identifier>PMID: 39735197</identifier><language>eng</language><publisher>Korea (South): Elsevier B.V</publisher><subject>High-intensity focused ultrasound ablation ; Partial gland ablation ; Whole gland ablation</subject><ispartof>Prostate international, 2024-12, Vol.12 (4), p.213-218</ispartof><rights>2024 The Asian Pacific Prostate Society</rights><rights>2024 The Asian Pacific Prostate Society. 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subjects High-intensity focused ultrasound ablation
Partial gland ablation
Whole gland ablation
title Whole gland versus partial gland ablation in patients with localized prostate cancer treated by high-intensity focused ultrasound ablation
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