Colchicine can keep the viability of bacteria in mastitic milk by preventing leukocyte phagocytosis in dairy cow and goat

Despite the occurrence of mastitis, no bacteria were detected in any of the milk samples after culture. This is partially because the neutrophils present in milk phagocytose bacteria during milk preservation. In this study, we investigated whether colchicine inhibited the decrease in viable bacteria...

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Bibliographic Details
Published in:Frontiers in veterinary science 2024-10, Vol.11, p.1469586
Main Authors: Hisaeda, Keiichi, Hirano, Masato, Suzuki, Naoki, Isobe, Naoki
Format: Article
Language:English
Subjects:
bacteria
colchicine
cow
goat
milk
phagocytosis
Veterinary Science
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Summary:Despite the occurrence of mastitis, no bacteria were detected in any of the milk samples after culture. This is partially because the neutrophils present in milk phagocytose bacteria during milk preservation. In this study, we investigated whether colchicine inhibited the decrease in viable bacteria in milk by suppressing phagocytosis during preservation. The number of viable bacteria decreased when cow milk was preserved for 5 h. However, the addition of 0.1 and 1% colchicine significantly increased the number of viable bacteria (  
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2024.1469586