Effects of a Fusarium Toxin-Contaminated Maize Treated with Sodium Sulfite on Male Piglets in the Presence of an LPS-Induced Acute Inflammation

• Published in: Toxins 2018-10, Vol.10 (10), p.419
• Main Authors: Tran, Anh-Tuan, Kluess, Jeannette, Berk, Andreas, Paulick, Marleen, Frahm, Jana, Schatzmayr, Dian, Kersten, Susanne, Dänicke, Sven
• Format: Article
• Language: English
• Subjects: Agricultural commodities; Animal Feed; Animals; Animals, Newborn; Body temperature; Body weight; Contamination; Corn; Deoxynivalenol; detoxification; Diet; Feeding; Feeds; Food Contamination; Fusarium; Hematology; Hogs; Inflammation - blood; Inflammation - chemically induced; Laboratory animals; Leukocyte Count; lipopolysaccharide; Lipopolysaccharides; Liver; Male; Metabolism; Neutrophils - immunology; Nutrition research; Organ Size - drug effects; Organic chemistry; piglets; Plasma; Rodents; Sodium; Sodium chloride; Sodium sulfite; Sulfite; Sulfites - pharmacology; Swine; Toxins; Trichothecenes - toxicity; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Zea mays - microbiology
• ISSN: 2072-6651; 2072-6651
• DOI: 10.3390/toxins10100419

We investigated the effects of feeding sodium sulfite (SoS) treated uncontaminated and contaminated maize in a porcine lipopolysaccharide (LPS) challenge model. Eighty piglets (7.59 ± 0.92 kg body weight [BW]) were equally assigned to one of four experimental diets containing 10% maize, either uncontaminated and untreated (CON-, 0.09 mg deoxynivalenol [DON]/kg diet) or uncontaminated and SoS-treated (CON+, wet-preserved with 5 g SoS/kg maize; 0.05 mg DON/kg diet), or prepared with 10% of a contaminated maize containing mainly deoxynivalenol (DON), either contaminated and untreated (FUS-, 5.36 mg DON/kg diet), or contaminated and SoS-treated (FUS+, wet-preserved with 5 g SoS/kg maize; 0.83 mg DON/kg diet). At day 42 of experiment, ten pigs of each group were injected intraperitoneally with either 7.5 µg LPS/kg BW or placebo (0.9% NaCl). At 120 min after injection, blood samples were collected to analyse TNF-α, hematological profile, clinical biochemistry as well as the redox status. A significant increase in body temperature and cytokine TNF-α concentration was observed in the LPS-injected piglets. Results for hematology, clinical chemistry and redox status indicate no effects of SoS treatment, with exception of neutrophil counts being significantly more pronounced after feeding the SoS treated FUS maize. In conclusion, SoS treatment of maize did not modulate the LPS-induced acute inflammation.