The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species

The anti-inflammatory and vasodilating effects of three selected dietary organic sulfur compounds (OSC), including diallyl disulfide (DADS), dimethyl disulfide (DMDS), and propyl disulfide (PDS), from species were investigated. In the anti-inflammatory activity assay, the three OSC demonstrated sign...

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Published in:Journal of functional biomaterials 2017-01, Vol.8 (1), p.5
Main Authors: Chu, Chin-Chen, Wu, Wen-Shiann, Shieh, Ja-Ping, Chu, Heuy-Ling, Lee, Chia-Pu, Duh, Pin-Der
Format: Article
Language:English
Subjects:
Angiotensin
angiotensin-converting enzyme
anti-inflammatory activity
Anti-inflammatory agents
Cyclooxygenase-2
Diallyl disulfide
dimethyl disulfide
Garlic
Hydrogen peroxide
Inflammation
Inflammatory response
Lipopolysaccharides
Nitric oxide
Nitric-oxide synthase
Organosulfur compounds
propyl disulfide
Prostacyclin
Prostaglandin E2
Sulfur
Sulfur compounds
vasodilation
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Summary:The anti-inflammatory and vasodilating effects of three selected dietary organic sulfur compounds (OSC), including diallyl disulfide (DADS), dimethyl disulfide (DMDS), and propyl disulfide (PDS), from species were investigated. In the anti-inflammatory activity assay, the three OSC demonstrated significant inhibition of nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in LPS-induced RAW 264.7 cells. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in activated RAW 264.7 cells was inhibited by the three OSC, indicating that the three OSC prevented the LPS-induced inflammatory response in RAW 264.7 cells. For the vasodilative assay, the three OSC were ineffective in producing NO in SVEC4-10 cells, but they did enhance prostacyclin (PGI₂) production. The expression of COX-2 in SVEC4-10 cells was activated by DADS and DMDS. Pretreatment of SVEC4-10 cells with the three OSC decreased ROS generation in H₂O₂-induced SVEC4-10 cells. In addition, the three OSC significantly inhibited angiotensin-I converting enzyme (ACE). The up-regulation of PGI₂ production and COX-2 expression by DADS and DMDS and the reduction of ROS generation by DADS, DMDS, and PDS in SVEC4-10 cells contributed to the vasodilative effect of the three OSC. Collectively, these findings suggest that DADS, DMDS, and PDS are potential anti-inflammatory and vasodilative mediators.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb8010005