A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuropr...

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Bibliographic Details
Published in:Frontiers in pharmacology 2018-02, Vol.9, p.104-104
Main Authors: Chen, Shao-Ru, Dai, Yan, Zhao, Jing, Lin, Ligen, Wang, Yitao, Wang, Ying
Format: Article
Language:English
Subjects:
celastrol
mechanisms of action
Pharmacology
structure-activity-relationship
Tripterygium wilfordii Hook F
triptolide
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Summary:Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol. We systemically discuss the structure-activity-relationship of triptolide, celastrol, and their derivatives. Furthermore, we propose the use of structural derivatives, targeted therapy, and combination treatment as possible solutions to reduce toxicity and increase therapeutic window of these potent natural products from Hook F.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2018.00104