SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders

The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays...

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Bibliographic Details
Published in:Microorganisms (Basel) 2020-07, Vol.8 (7), p.1052
Main Authors: Benazzo, Marco, Cassaniti, Irene, Maiorano, Eugenia, Calastri, Anna, Novazzi, Federica, Bonetti, Alice, Sarasini, Antonella, Bruno, Raffaele, Baldanti, Fausto
Format: Article
Language:English
Subjects:
ageusia
Anosmia
Chemotherapy
Communication
Coronaviruses
COVID-19
Disease transmission
Disorders
Epidemics
Immunoglobulin G
Infections
Laboratories
Middle East respiratory syndrome
Patients
Public health
Questionnaires
Respiratory diseases
Ribonucleic acid
RNA
RNA polymerase
SARS-CoV-2
Serology
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Taste
Viral infections
Viruses
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Summary:The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays for the characterization of SARS-CoV-2 IgG and SARS-CoV-2 RNA, respectively, were performed at the time of enrolment and after 7 and 14 days. Patients were stratified according to the symptoms' onset. A total of 52 patients (75.4%) were diagnosed as COVID-19 positive being SARS-CoV-2 RNA and/or SARS-CoV-2 IgG positive. The remaining 17 (24.6%) were negative for COVID-19 and excluded from the analysis. We reported that only 34 out of 52 patients (65.4%) were positive for SARS-CoV-2 RNA. Moreover, the median time from onset of symptoms and enrolment was significantly higher in those patients with negative SARS-CoV-2 RNA in nasal swabs, suggesting that symptoms might last longer than SARS-CoV-2 replication. The great majority of patients (80%) developed SARS-CoV-2 IgG at three weeks after symptoms' onset while the detectability of SARS-CoV-2 RNA dramatically decreased over time, suggesting the crucial role of combination of molecular and serological assays for the diagnosis of COVID-19 in those patients reporting mild symptoms.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms8071052