Pichia pastoris (Komagataella phaffii) as a Cost-Effective Tool for Vaccine Production for Low- and Middle-Income Countries (LMICs)

Vaccination is of paramount importance to global health. With the advent of the more recent pandemics, the urgency to expand the range has become even more evident. However, the potential limited availability and affordability of vaccines to resource low- and middle-income countries has created a ne...

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Bibliographic Details
Published in:Bioengineering (Basel) 2021-08, Vol.8 (9), p.119
Main Authors: de Sá Magalhães, Salomé, Keshavarz-Moore, Eli
Format: Article
Language:English
Subjects:
Bacteria
Bioengineering
Biotechnology
Case studies
Costs
COVID-19
Ebola virus
expression platforms
Fermentation
Genetic engineering
Income
Infectious diseases
Komagataella phaffii
LMICs
Manufacturing
P. pastoris (Komagataella phaffii)
Pandemics
Pathogens
Pichia pastoris
Production costs
Production methods
Protein expression
Proteins
Public health
Review
Success
SWOT analysis
Vaccine development
Vaccines
Yeast
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Summary:Vaccination is of paramount importance to global health. With the advent of the more recent pandemics, the urgency to expand the range has become even more evident. However, the potential limited availability and affordability of vaccines to resource low- and middle-income countries has created a need for solutions that will ensure cost-effective vaccine production methods for these countries. Pichia pastoris (P. pastoris) (also known as Komagataella phaffii) is one of the most promising candidates for expression of heterologous proteins in vaccines development. It combines the speed and ease of highly efficient prokaryotic platforms with some key capabilities of mammalian systems, potentially reducing manufacturing costs. This review will examine the latest developments in P. pastoris from cell engineering and design to industrial production systems with focus on vaccine development and with reference to specific key case studies.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering8090119