TULA-Family Regulators of Platelet Activation

The two members of the UBASH3/TULA/STS-protein family have been shown to critically regulate cellular processes in multiple biological systems. The regulatory function of TULA-2 (also known as UBASH3B or STS-1) in platelets is one of the best examples of the involvement of UBASH3/TULA/STS proteins i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (23), p.14910
Main Authors: Kunapuli, Satya P, Tsygankov, Alexander Y
Format: Article
Language:English
Subjects:
Biological activity
Blood Platelets - metabolism
Collagen
Dephosphorylation
Enzymatic activity
Enzyme kinetics
Glycoproteins
hemITAM
ITAM
Kinases
Lymphocytes
Peptides
Phosphatase
Phosphorylation
Phosphorylation - physiology
Physiology
platelet
Platelet Activation
Protein structure
Protein-tyrosine kinase
Proteins
Regulation
Review
Signal Transduction
signaling
Syk
Syk Kinase - metabolism
Syk protein
Tyrosine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The two members of the UBASH3/TULA/STS-protein family have been shown to critically regulate cellular processes in multiple biological systems. The regulatory function of TULA-2 (also known as UBASH3B or STS-1) in platelets is one of the best examples of the involvement of UBASH3/TULA/STS proteins in cellular regulation. TULA-2 negatively regulates platelet signaling mediated by ITAM- and hemITAM-containing membrane receptors that are dependent on the protein tyrosine kinase Syk, which currently represents the best-known dephosphorylation target of TULA-2. The biological responses of platelets to collagen and other physiological agonists are significantly downregulated as a result. The protein structure, enzymatic activity and regulatory functions of UBASH3/TULA/STS proteins in the context of platelet responses and their regulation are discussed in this review.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232314910