Remdesivir Prescription in Pregnant Women Infected with COVID-19: A Report of Compassionate Use

• Published in: Advanced biomedical research 2023-01, Vol.12 (1), p.163-163
• Main Authors: Zafarbakhsh, Azam, Vaezi, Atefeh, Haghjooy Javanmard, Shaghayegh, Sabet, Fahimeh, Dehghan, Maryam
• Format: Article
• Language: English
• Subjects: covid-19; Original; pregnancy; remdesivir
• ISSN: 2277-9175; 2277-9175
• DOI: 10.4103/abr.abr_142_22

Coronavirus disease 2019 (COVID-19) is an infectious disease that the physiological changes in pregnancy can make pregnant patients more susceptible to more severe forms of this infection. Hence, the treatment of COVID-19 in pregnant women can be challenging. This study was designed to evaluate the safety and efficacy of Remdesivir in pregnant women with COVID-19. This study was conducted on 150 pregnant women with moderate to severe COVID-19 infection. Remdesivir was prescribed and continued for 5 or 10 days according to the patient's condition. Maternal and pregnancy outcomes and also recovery rates were evaluated. Moreover, additional variables were examined: age, gestational age, symptoms, O2 saturation and laboratory tests at admission, the interval between symptom initiation and admission to hospital and Remdesivir prescription, hospitalization days, and ICU admission. The mean age was 32.37 years. Cough and dyspnea were the most prevalent symptoms (74% and 68.7%, respectively). At the time of admission, 79 (52.7%) women needed low-flow oxygen support, 67 (44.7%) needed high-flow oxygen support, and 4 (2.7%) were intubated. Fifty-four (36%) patients required ICU care. In patients who died (12 women), Remdesivir was prescribed later than those discharged ( value, 0.04). Patients with favorable pregnancy outcomes received Remdesivir earlier than those with unfavorable pregnancy outcomes ( value: 0.008). The recovery rate was 70% (89.9% in the low-flow oxygen, 50.7% in the NIPPV/high flow oxygen, and 0% in the intubated women). The results suggest that the early prescription of Remdesivir in pregnant women with moderate COVID-19 can improve the outcomes.