Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1

• Published in: Genomics, proteomics & bioinformatics proteomics & bioinformatics, 2017-06, Vol.15 (3), p.208-217
• Main Authors: Jiang, Lanfang, Zhao, Zitong, Zheng, Leilei, Xue, Liyan, Zhan, Qimin, Song, Yongmei
• Format: Article
• Language: English
• Subjects: Cyclin D1; Esophageal squamous cell carcinoma; Migration and invasion; miR-503; Original Research; Proliferation; 侵袭性; 增殖; 抗肿瘤作用; 细胞周期蛋白D1; 肿瘤抑制基因; 迁移; 食管癌细胞; 鳞状细胞癌
• ISSN: 1672-0229; 2210-3244
• DOI: 10.1016/j.gpb.2017.04.003

Esophageal squamous cell carcinoma （ESCC） is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of micro- RNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues. Fur- ther investigation in the effect of miR-503 on ESCC cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpres- sion of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype. Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1.