New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy

Background. The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis. Methods and Results. N=25 patients with clinical...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.121-129
Main Authors: Kasner, Mario, Escher, Felicitas, Kühl, Uwe, Heymer, Johannes, Wilkenshoff, Ursula, Tschöpe, Carsten, Schultheiss, Heinz-Peter
Format: Article
Language:English
Subjects:
Adult
Biopsy
Cardiomyopathies - immunology
Cardiomyopathies - metabolism
Cardiomyopathies - pathology
Cardiomyopathy
Care and treatment
Clinical Study
Diagnosis
Echocardiography
Echocardiography - methods
Female
Health aspects
Heart diseases
Humans
In Vitro Techniques
Inflammation - metabolism
Inflammation - pathology
Male
Middle Aged
Myocarditis
Myocarditis - immunology
Myocarditis - metabolism
Myocarditis - pathology
Risk factors
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Summary:Background. The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis. Methods and Results. N=25 patients with clinically diagnosed AMC who underwent endomyocardial biopsies (EMBs) were studied prospectively. Speckle tracking imaging was examined at the beginning and during a mean follow-up period of 6.2 months. In the acute phase patients had markedly decreased left ventricular (LV) systolic function (mean LV ejection fraction (LVEF) 40.4±10.3%). At follow-up in n=8 patients, inflammation persists, correlating with a significantly reduced fractional shortening (FS, 21.5±6.0%) in contrast to those without inflammation in EMB (FS 32.1±7.1%, P
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/875420