Recurrence Patterns after Radiotherapy for Glioblastoma with [(11)C]methionine Positron Emission Tomography-Guided Irradiation for Target Volume Optimization

C methionine ( C-MET) is increasingly being used in addition to contrast-enhanced MRI to plan for radiotherapy of patients with glioblastomas. This study aimed to assess the recurrence pattern quantitatively. Glioblastoma patients undergoing 11C-MET PET examination before primary radiotherapy from 2...

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Bibliographic Details
Published in:Diagnostics (Basel) 2024-05, Vol.14 (9), p.964
Main Authors: Debreczeni-Máté, Zsanett, Törő, Imre, Simon, Mihaly, Gál, Kristof, Barabás, Marton, Sipos, David, Kovács, Arpad
Format: Article
Language:English
Subjects:
11C MET PET
Amino acids
Biopsy
Brain cancer
Chemotherapy
Development and progression
glioblastoma
Glioblastoma multiforme
Glioma
Magnetic resonance imaging
Medical imaging equipment
Medical research
Medicine, Experimental
Oncology
Patients
PET imaging
Radiation therapy
Radiotherapy
recurrence pattern
Surgery
Tomography
Tumors
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Summary:C methionine ( C-MET) is increasingly being used in addition to contrast-enhanced MRI to plan for radiotherapy of patients with glioblastomas. This study aimed to assess the recurrence pattern quantitatively. Glioblastoma patients undergoing 11C-MET PET examination before primary radiotherapy from 2018 to 2023 were included in the analysis. A clinical target volume was manually created and fused with MRI-based gross tumor volumes and MET PET-based biological target volume. The recurrence was noted as an area of contrast enhancement on the first MRI scan, which showed progression. The recurrent tumor was identified on the radiological MR images in terms of recurrent tumor volume, and recurrences were classified as central, in-field, marginal, or ex-field tumors. We then compared the MET-PET-defined biological target volume with the MRI-defined recurrent tumor volume regarding spatial overlap (the Dice coefficient) and the Hausdorff distance. Most recurrences occurred locally within the primary tumor area (64.8%). The mean Hausdorff distance was 39.4 mm (SD 32.25), and the mean Dice coefficient was 0.30 (SD 0.22). In patients with glioblastoma, the analysis of the recurrence pattern has been mainly based on FET-PET. Our study confirms that the recurrence pattern after gross tumor volume-based treatment contoured by MET-PET is consistent with the FET-PET-based treatment described in the literature.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14090964