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Topical Fibronectin Improves Wound Healing of Irradiated Skin
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, f...
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| Published in: | Scientific reports 2017-06, Vol.7 (1), p.3876-10, Article 3876 |
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| creator | Johnson, Maxwell B. Pang, Brandon Gardner, Daniel J. Niknam-Benia, Solmaz Soundarajan, Vinaya Bramos, Athanasios Perrault, David P. Banks, Kian Lee, Gene K. Baker, Regina Y. Kim, Gene H. Lee, Sunju Chai, Yang Chen, Mei Li, Wei Kwong, Lawrence Hong, Young-Kwon Wong, Alex K. |
| description | Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds. |
| doi_str_mv | 10.1038/s41598-017-03614-y |
| format | article |
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To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-03614-y</identifier><identifier>PMID: 28634413</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 38 ; 64/60 ; 692/4017 ; 692/699/4033 ; 82 ; 82/1 ; 82/79 ; 82/80 ; Administration, Topical ; Angiogenesis ; Animal models ; Animals ; Disease Models, Animal ; Fibronectin ; Fibronectins - administration & dosage ; Humanities and Social Sciences ; Humans ; Inflammation ; Male ; Mice ; multidisciplinary ; Protein Array Analysis ; Protein arrays ; Radiation Injuries - drug therapy ; Radiation Injuries - metabolism ; Radiation Injuries - pathology ; Science ; Science (multidisciplinary) ; Skin ; Skin - drug effects ; Skin - injuries ; Skin - metabolism ; Skin - pathology ; Wound Healing</subject><ispartof>Scientific reports, 2017-06, Vol.7 (1), p.3876-10, Article 3876</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jun 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-f3cad1fb114546347d3485447546cf0903603b384194a42ca98436f6223201523</citedby><cites>FETCH-LOGICAL-c540t-f3cad1fb114546347d3485447546cf0903603b384194a42ca98436f6223201523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1955672413/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1955672413?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28634413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Maxwell B.</creatorcontrib><creatorcontrib>Pang, Brandon</creatorcontrib><creatorcontrib>Gardner, Daniel J.</creatorcontrib><creatorcontrib>Niknam-Benia, Solmaz</creatorcontrib><creatorcontrib>Soundarajan, Vinaya</creatorcontrib><creatorcontrib>Bramos, Athanasios</creatorcontrib><creatorcontrib>Perrault, David P.</creatorcontrib><creatorcontrib>Banks, Kian</creatorcontrib><creatorcontrib>Lee, Gene K.</creatorcontrib><creatorcontrib>Baker, Regina Y.</creatorcontrib><creatorcontrib>Kim, Gene H.</creatorcontrib><creatorcontrib>Lee, Sunju</creatorcontrib><creatorcontrib>Chai, Yang</creatorcontrib><creatorcontrib>Chen, Mei</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Kwong, Lawrence</creatorcontrib><creatorcontrib>Hong, Young-Kwon</creatorcontrib><creatorcontrib>Wong, Alex K.</creatorcontrib><title>Topical Fibronectin Improves Wound Healing of Irradiated Skin</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.</description><subject>13/51</subject><subject>38</subject><subject>64/60</subject><subject>692/4017</subject><subject>692/699/4033</subject><subject>82</subject><subject>82/1</subject><subject>82/79</subject><subject>82/80</subject><subject>Administration, Topical</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Fibronectin</subject><subject>Fibronectins - administration & dosage</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Protein Array Analysis</subject><subject>Protein arrays</subject><subject>Radiation Injuries - drug therapy</subject><subject>Radiation Injuries - metabolism</subject><subject>Radiation Injuries - 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Rep</addtitle><date>2017-06-20</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>3876</spage><epage>10</epage><pages>3876-10</pages><artnum>3876</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28634413</pmid><doi>10.1038/s41598-017-03614-y</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/51 38 64/60 692/4017 692/699/4033 82 82/1 82/79 82/80 Administration, Topical Angiogenesis Animal models Animals Disease Models, Animal Fibronectin Fibronectins - administration & dosage Humanities and Social Sciences Humans Inflammation Male Mice multidisciplinary Protein Array Analysis Protein arrays Radiation Injuries - drug therapy Radiation Injuries - metabolism Radiation Injuries - pathology Science Science (multidisciplinary) Skin Skin - drug effects Skin - injuries Skin - metabolism Skin - pathology Wound Healing |
| title | Topical Fibronectin Improves Wound Healing of Irradiated Skin |
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