Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae

Ubiquitination is a reversible protein post-translational modification that regulates various pivotal physiological and pathological processes in all eukaryotes. Recently, the antiviral immune response is enhanced by the regulation of ubiquitination. Intriguingly, Flaviviridae viruses can ingeniousl...

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Bibliographic Details
Published in:Frontiers in microbiology 2022-05, Vol.13, p.835344-835344
Main Authors: Cai, Dongjie, Liu, Lingli, Tian, Bin, Fu, Xingxin, Yang, Qiyuan, Chen, Jie, Zhang, Yilin, Fang, Jing, Shen, Liuhong, Wang, Ya, Gou, Liping, Zuo, Zhicai
Format: Article
Language:English
Subjects:
antiviral immunity
CSFV
Flaviviridae
HCV
Microbiology
TRIM proteins
ubiquitin system
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Summary:Ubiquitination is a reversible protein post-translational modification that regulates various pivotal physiological and pathological processes in all eukaryotes. Recently, the antiviral immune response is enhanced by the regulation of ubiquitination. Intriguingly, Flaviviridae viruses can ingeniously hijack the ubiquitination system to help them survive, which has become a hot topic among worldwide researchers. The Flaviviridae family members, such as HCV and CSFV, can cause serious diseases of humans and animals around the world. The multiple roles of ubiquitination involved in the life cycle of Flaviviridae family would open new sight for future development of antiviral tactic. Here, we discuss recent advances with regard to functional roles of ubiquitination and some ubiquitin-like modifications in the life cycle of Flaviviridae infection, shedding new light on the antiviral mechanism research and therapeutic drug development.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.835344