Identification of functional circRNAs regulating ovarian follicle development in goats

Circular RNAs (circRNAs) play important regulatory roles in a variety of biological processes in mammals. Multiple birth-traits in goats are affected by several factors, but the expression and function of circRNAs in follicular development of goats are not clear. In this study, we aimed to investiga...

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Bibliographic Details
Published in:BMC genomics 2024-09, Vol.25 (1), p.893-17, Article 893
Main Authors: Liu, Jie, Feng, Guanghang, Guo, Conghui, Li, Zhihan, Liu, Dewu, Liu, Guangbin, Zou, Xian, Sun, Baoli, Guo, Yongqing, Deng, Ming, Li, Yaokun
Format: Article
Language:English
Subjects:
Animal genetics
Animals
Apoptosis
Autophagy
Biological activity
Cell proliferation
Cell size
circCFAP20DC
Circular RNA
Female
Flow cytometry
Follicles
Follicular development
Gene Expression Profiling
Gene flow
Gene Regulatory Networks
Gene sequencing
Genes
Genetic aspects
Genetic research
Genomes
Goats
Goats - genetics
Gonadotropin-releasing hormone
Granulosa cells
Identification and classification
Leizhou goat
MicroRNAs
MicroRNAs - genetics
Multiple births
Ovarian Follicle - growth & development
Ovarian Follicle - metabolism
Ovaries
Ovulation
Oxytocin
Physiological aspects
Regulatory mechanisms (biology)
Reproduction
Retinoblastoma
Ribonucleic acid
RNA
RNA sequencing
RNA, Circular - genetics
S phase
Sequence Analysis, RNA
Signal transduction
Steroidogenesis
Western blotting
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Summary:Circular RNAs (circRNAs) play important regulatory roles in a variety of biological processes in mammals. Multiple birth-traits in goats are affected by several factors, but the expression and function of circRNAs in follicular development of goats are not clear. In this study, we aimed to investigate the possible regulatory mechanisms of circRNA and collected five groups of large follicles (Follicle diameter > 6 mm) and small follicles (1 mm 
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-024-10834-w